Integrating analog and digital modes of gene expression at
A. thaliana
FLC
Single molecule RNA FISH
chromosomes
computational biology
gene expression
mathematical modeling
quantitative gene expression
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 07 2023
19 07 2023
Historique:
received:
25
04
2022
accepted:
25
06
2023
medline:
21
7
2023
pubmed:
19
7
2023
entrez:
19
7
2023
Statut:
epublish
Résumé
Quantitative gene regulation at the cell population level can be achieved by two fundamentally different modes of regulation at individual gene copies. A 'digital' mode involves binary ON/OFF expression states, with population-level variation arising from the proportion of gene copies in each state, while an 'analog' mode involves graded expression levels at each gene copy. At the
Identifiants
pubmed: 37466633
doi: 10.7554/eLife.79743
pii: 79743
pmc: PMC10356135
doi:
pii:
Substances chimiques
Arabidopsis Proteins
0
MADS Domain Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P020380/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P013511/1
Pays : United Kingdom
Informations de copyright
© 2023, Antoniou-Kourounioti, Meschichi, Reeck et al.
Déclaration de conflit d'intérêts
RA, AM, SR, SB, GM, YZ, JF, TH, LZ, HW, MH, CD, SR, MH No competing interests declared
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