Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy.
cognitive impairment
focal epilepsy
magnetic resonance imaging
white matter tracts
Journal
Epilepsia open
ISSN: 2470-9239
Titre abrégé: Epilepsia Open
Pays: United States
ID NLM: 101692036
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
05
10
2022
accepted:
14
07
2023
medline:
5
9
2023
pubmed:
20
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
To investigate how the presence/side of hippocampal sclerosis (HS) are related to the white matter structure of cingulum bundle (CB), arcuate fasciculus (AF), and inferior longitudinal fasciculus (ILF) in mesial temporal lobe epilepsy (MTLE). We acquired diffusion-weighted magnetic resonance imaging (MRI) from 86 healthy and 71 individuals with MTLE (22 righ-HS; right-HS, 34 left-HS; left-HS, and 15 nonlesional MTLE). We utilized two-tensor tractography and fiber clustering to compare fractional anisotropy (FA) of each side/tract between groups. Additionally, we examined the association between FA and nonverbal (WMS-R) and verbal (WMS-R, RAVLT codification) memory performance for MTLE individuals. White matter abnormalities depended on the side and presence of HS. The left-HS demonstrated widespread abnormalities for all tracts, the right-HS showed lower FA for ipsilateral tracts and the nonlesional MTLE group did not differ from healthy individuals. Results indicate no differences in verbal/nonverbal memory performance between the groups, but trend-level associations between higher FA of visual memory and the left CB (r = 0.286, P = 0.018), verbal memory (RAVLT) and -left CB (r = 0.335, P = 0.005), -right CB (r = 0.286, P = 0.016), and -left AF (r = 0.287, P = 0.017). Our results highlight that the presence and side of HS are crucial to understand the pathophysiology of MTLE. Specifically, left-sided HS seems to be related to widespread bilateral white matter abnormalities. Future longitudinal studies should focus on developing diagnostic and treatment strategies dependent on HS's presence/side.
Identifiants
pubmed: 37469213
doi: 10.1002/epi4.12793
pmc: PMC10472386
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1111-1122Subventions
Organisme : NIMH NIH HHS
ID : K24 MH110807
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119222
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH074794
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH115247
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015902
Pays : United States
Informations de copyright
© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
Références
Brain. 2009 Mar;132(Pt 3):570-82
pubmed: 19251757
Neurology. 2015 May 5;84(18):1846-53
pubmed: 25854868
Quant Imaging Med Surg. 2015 Apr;5(2):247-63
pubmed: 25853083
Neurosci Biobehav Rev. 2018 Sep;92:104-127
pubmed: 29753752
J Neurotrauma. 2021 Dec;38(23):3279-3287
pubmed: 34605664
Epilepsia Open. 2023 Sep;8(3):1111-1122
pubmed: 37469213
Front Hum Neurosci. 2021 Apr 14;15:605213
pubmed: 33935667
Epilepsy Behav. 2014 Jun;35:42-9
pubmed: 24798409
JCO Clin Cancer Inform. 2020 Mar;4:299-309
pubmed: 32216636
Ann Neurol. 2003 Mar;53(3):413-6
pubmed: 12601713
Epilepsia. 2011 Dec;52(12):2257-66
pubmed: 21972957
Hum Neurobiol. 1985;4(3):137-42
pubmed: 4066424
AJNR Am J Neuroradiol. 2009 Oct;30(9):1740-7
pubmed: 19509072
Ann Neurol. 2005 Feb;57(2):188-96
pubmed: 15562425
Acta Neurol Belg. 2020 Dec;120(6):1323-1331
pubmed: 30635771
Neuroimage. 2014 Oct 15;100:135-44
pubmed: 24814212
J Neurol. 2020 Apr;267(4):1179-1187
pubmed: 31925497
Epilepsy Res. 2008 Jul;80(1):30-41
pubmed: 18436432
Med Image Comput Comput Assist Interv. 2012;15(Pt 3):123-30
pubmed: 23286122
Epilepsy Behav. 2014 Jul;36:108-14
pubmed: 24907496
Brain. 2020 Aug 1;143(8):2454-2473
pubmed: 32814957
J Cogn Neurosci. 2004 Sep;16(7):1227-33
pubmed: 15453975
Brain. 2009 Oct;132(Pt 10):2822-30
pubmed: 19635728
Acta Neuropathol. 2014 Jul;128(1):21-37
pubmed: 24823761
Neurology. 2016 May 17;86(20):1904-10
pubmed: 27164663
Lancet Neurol. 2019 Apr;18(4):357-375
pubmed: 30773428
Neuroimage. 2018 Oct 1;179:429-447
pubmed: 29920375
Neuroimage. 2022 Feb 1;246:118739
pubmed: 34856375
Cortex. 2017 Sep;94:1-14
pubmed: 28710907
Epilepsia. 2019 Jun;60(6):1054-1068
pubmed: 31135062
Epilepsia. 2017 May;58(5):727-742
pubmed: 28266710
Epilepsia. 2015 Jul;56(7):1109-16
pubmed: 26096728
Neurology. 2008 Dec 2;71(23):1869-76
pubmed: 18946001
IEEE Trans Med Imaging. 2010 Sep;29(9):1664-75
pubmed: 20805043
Epilepsia. 2012 Apr;53(4):659-67
pubmed: 22379949
Epilepsy Behav. 2018 Jan;78:302-312
pubmed: 29097123
Front Neuroanat. 2018 Sep 19;12:77
pubmed: 30283306
Epilepsia. 2013 Jul;54(7):1315-29
pubmed: 23692496
Epilepsia. 2010 Apr;51(4):536-45
pubmed: 20132296
Front Neurol. 2019 Apr 24;10:394
pubmed: 31068889
Epilepsia. 2010 Apr;51(4):676-85
pubmed: 20196795
Nat Rev Neurol. 2011 Mar;7(3):154-64
pubmed: 21304484
J Neurol Neurosurg Psychiatry. 2009 Mar;80(3):312-9
pubmed: 18977826
Brain. 2018 Feb 1;141(2):391-408
pubmed: 29365066
AJNR Am J Neuroradiol. 2014 Jan;35(1):77-83
pubmed: 23868151
Epilepsy Behav. 2021 Aug;121(Pt B):106523
pubmed: 31645315
Neuroimage. 2008 Apr 1;40(2):728-737
pubmed: 18261930
Epilepsia. 2011 Jul;52 Suppl 4:32-4
pubmed: 21732939
Eur J Radiol. 2008 Jan;65(1):86-90
pubmed: 17553646
Hum Brain Mapp. 2019 Jul;40(10):3041-3057
pubmed: 30875144
Hum Brain Mapp. 2015 Jan;36(1):85-98
pubmed: 25137314