Oxytocin response to food intake in avoidant/restrictive food intake disorder.
avoidant/restrictive food intake disorder
feeding and eating disorders
food control
hypothalamus
oxytocin
Journal
European journal of endocrinology
ISSN: 1479-683X
Titre abrégé: Eur J Endocrinol
Pays: England
ID NLM: 9423848
Informations de publication
Date de publication:
02 Aug 2023
02 Aug 2023
Historique:
received:
22
03
2023
revised:
16
05
2023
accepted:
07
06
2023
pmc-release:
20
07
2024
medline:
4
8
2023
pubmed:
21
7
2023
entrez:
20
7
2023
Statut:
ppublish
Résumé
To investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in food or eating, sensory sensitivity to food, and/or fear of aversive consequences of eating, compared with healthy controls (HC). Cross-sectional. A total of 109 participants (54 with ARFID spectrum and 55 HC) were instructed to eat a ∼400-kcal standardized mixed meal. We sampled serum oxytocin at fasting and at 30-, 60-, and 120-min postmeal. We tested the hypothesis that ARFID would show higher mean oxytocin levels across time points compared with HC using a mixed model ANOVA. We then used multivariate regression analysis to identify the impact of clinical characteristics (sex, age, and body mass index [BMI] percentile) on oxytocin levels in individuals with ARFID. Participants with ARFID exhibited greater mean oxytocin levels at all time points compared with HC, and these differences remained significant even after controlling for sex and BMI percentile (P = .004). Clinical variables (sex, age, and BMI percentile) did not show any impact on fasting and postprandial oxytocin levels among individuals with ARFID. Consistently high oxytocin levels might be involved in low appetite and sensory aversions to food, contributing to food avoidance in individuals with ARFID.
Identifiants
pubmed: 37474111
pii: 7227255
doi: 10.1093/ejendo/lvad087
pmc: PMC10396082
doi:
Substances chimiques
Oxytocin
50-56-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-155Subventions
Organisme : NIMH NIH HHS
ID : R01 MH103402
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH108595
Pays : United States
Organisme : NIH HHS
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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