Engineering of functional nanosnowflakes from gold nanocarriers capped with amino-modified DNA oligonucleotides.
amine-modified oligonucleotides
gold nanocarriers
nanosnowflakes
Journal
Microscopy research and technique
ISSN: 1097-0029
Titre abrégé: Microsc Res Tech
Pays: United States
ID NLM: 9203012
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
06
06
2023
accepted:
10
07
2023
medline:
14
8
2023
pubmed:
21
7
2023
entrez:
21
7
2023
Statut:
ppublish
Résumé
The design, engineering and electron microscopic characterization of anisotropic nanosized snowflake-like structural assemblies (nanosnowflakes) is reported. They were fabricated through immobilization of double stranded amine-modified and thiol-terminated DNA oligonucleotides on the surface of ultra-small isotropic gold nanoparticles used as nanocarriers. The transmission electron microscopy images combined with spectrophotometric data revealed the formation of self-assembled structural aggregation between individual ligands-coated nanoparticles. They act as seeds for the further spontaneous dendritic growth in different directions. Their anisotropic morphology is formed due to the occurrence of facilitated electrostatic interactions between positive charged amino-groups and the negative sugar-phosphate backbone of oligonucleotides. Thus, nanosnowflakes with size distribution between 40 and 80 nm were obtained. The microscopic analysis demonstrated also that the stable nanosnowflakes structure was highly dependent on the solution ionic strength, which effect the charge fluctuation within the assembly. The reported DNA functionalized nanostructures have potential to be applied as a platform for development of therapeutic materials, as well as drug delivery nanosystems. RESEARCH HIGHLIGHTS: The engineering, fabrication, and microscopic characterization of DNA nanosnowflakes is reported. The electron microscopy analysis revealed formation of self-assemblies with anisotropic morphology. The nanosnowflakes size distribution was between 40 and 80 nm.
Substances chimiques
Oligonucleotides
0
Gold
7440-57-5
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1169-1176Subventions
Organisme : MEXT/JSPS KAKENHI
ID : T20K05260
Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
Alle, M., Sharma, G., Lee, S.-H., & Kim, J.-C. (2022). Next-generation engineered nanogold for multimodal cancer therapy and imaging: A clinical perspectives. Journal of Nanbiotechnology, 20, 222.
Amendola, V., Pilot, R., Frasconi, M., Maragò, O. M., & Iatì, M. A. (2017). Surface plasmon resonance in gold nanoparticles: A review. Journal of Physics. Condensed Matter, 29, 203002.
Anik, M. I., Mahmud, N., Masud, A. A., & Hasan, M. (2022). Gold nanoparticles (GNPs) in biomedical and clinical applications: A review. Nano Select, 3, 733-881.
Arvizo, R., Bhattacharya, R., & Mukherjee, P. (2010). Gold nanoparticles: Opportunities and challenges in nanomedicine. Expert Opinion on Drug Delivery, 7, 753-763.
Badia, A., Demers, L., Dickinson, L., Morin, F. G., Lennox, R. B., & Reven, L. (1997). Gold−sulfur interactions in alkylthiol self-assembled monolayers formed on gold nanoparticles studied by solid-state NMR. Journal of the American Chemical Society, 119, 11104-11105.
Bailly, A.-L., Correard, F., Popov, A., Tselikov, G., Chaspoul, F., Appay, R., Al-Kattan, A., Kabashin, A. V., Braguer, D., & Esteve, M.-A. (2019). In vivo evaluation of safety, biodistribution and pharmacokinetics of laser-synthesized gold nanoparticles. Scientific Reports, 9, 12890.
Bansal, S. A., Kumar, V., Karimi, J., Singh, A. P., & Kumar, S. (2020). Role of gold nanoparticles in advanced biomedical applications. Nanoscale Advances, 2, 3764-3787.
Cabuzu, D., Cirja, A., Puiu, R., & Grumezescu, A. M. (2015). Biomedical applications of gold nanoparticles. Current Topics in Medicinal Chemistry, 15, 1605-1613.
Chaudhuri, P. (2014). AA-Dutp-Cy3 a novel fluorescent labeling agent for nucleotides. Biochemical Pharmacology, 3, 1000137.
Durymanov, M. O., Rosenkranz, A. A., & Sobolev, A. A. (2015). Current approaches for improving intratumoral accumulation and distribution of nanomedicines. Theranostics, 5, 1007-1020.
Elahi, N., Kamali, M., & Baghersad, M. H. (2018). Recent biomedical applications of gold nanoparticles: A review. Talanta, 184, 537-556.
Fan, M., Han, Y., Gao, S., Yan, H., Cao, L., Li, Z., Liang, X.-J., & Zhang, J. (2020). Ultrasmall gold nanoparticles in cancer diagnosis and therapy. Theranostics, 10, 4944-4957.
Huang, X., & El-Sayed, M. A. (2010). Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy. Journal of Advanced Research, 1, 13-28.
Jain, S., Hirst, D. G., & O'Sullivan, J. M. (2012). Gold nanoparticles as novel agents for cancer therapy. The British Journal of Radiology, 85, 101-113.
Lee, J., Chatterjee, D. K., Lee, M. H., & Krishnan, S. (2014). Gold nanoparticles in breast cancer treatment: Promise and potential pitfalls. Cancer Letters, 347, 46-53.
Loukanov, A., Kamasawa, N., Danev, R., Shigemoto, R., & Nagayama, K. (2010). Immunolocalization of multiple membrane proteins on a carbon replica with STEM and EDX. Ultramicroscopy, 110, 366-374.
Loukanov, A., Zhelyazkov, V., Hihara, Y., & Nakabayashi, S. (2016). Intracellular imaging of Qdots-labeled DNA in cyanobacteria. Microscopy Research and Technique, 79, 447-452.
Loukanov, A. R., & Emin, S. (2012). Quantum dots for detection, identification and tracking of single biomolecules in tissue and cells. In Intelligent nanomaterials: Processes, properies, and applications (pp. 649-677). Scrivener Publishing LCC.
Loukanov, A. R., & Gagov, H. (2012). High-resolution subunit detection of glutamate receptor by ultrasmall gold nanoparticles. Microscopy Research and Technique, 75, 1159-1164.
Mundekkad, D., & Cho, W. C. (2022). Nanoparticles in clinical translation for cancer therapy. International Journal of Molecular Sciences, 23, 1685.
Parab, H., Jung, C., Woo, M. A., & Park, H. G. (2011). An anisotropic snowflake-like structural assembly of polymer-capped gold nanoparticles. Journal of Nanoparticle Research, 13, 2173-2180.
Reimers, J. R., Ford, M. J., Halder, A., Ulstrup, J., & Hush, N. S. (2016). Gold surfaces and nanoparticles are protected by Au(0)-thiyl species and are destroyed when Au(I)-thiolates form. PNAS, 113, E1424-E1433.
Rzigalinski, B. A. (2005). Nanoparticles and cell longevity. Technology in Cancer Research & Treatment, 4, 651-659.
Tjong, V., Yu, H., Hucknall, A., & Chilkoti, A. (2013). Direct fluorescence detection of RNA on microarrays by surface initiated enzymatic polymerization. Analytical Chemistry, 85, 426-433.
Ud Din, F., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017). Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. International Journal of Nanomedicine, 12, 7291-7309.