Advanced in vitro hemocompatibility assessment of biomaterials using a new flow incubation system.

Biocompatible Materials / adverse effects Blood Platelets Platelet Activation Hemostasis
Hemocompatibility In vitro testing Perfusion chamber Shear stress Whole blood

Journal

Biomaterials advances
ISSN: 2772-9508
Titre abrégé: Biomater Adv
Pays: Netherlands
ID NLM: 9918383886206676

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 29 03 2023
revised: 21 06 2023
accepted: 06 07 2023
medline: 1 9 2023
pubmed: 22 7 2023
entrez: 21 7 2023
Statut: ppublish

Résumé

Physiologically relevant in vitro hemocompatibility assessment of biomaterials remains challenging. We present a new setup that enables standardized whole blood incubation of biomedical materials under flow. A blood volume of 2 mL is recirculated over test surfaces in a custom-made parallel plate incubation system to determine the activation of hemostasis and inflammation. Controlled physiological shear rates between 125 s

Identifiants

DOI: 10.1016/j.bioadv.2023.213555 PMID: 37478769
pubmed: 37478769
pii: S2772-9508(23)00278-9
doi: 10.1016/j.bioadv.2023.213555
pii:
doi:

Substances chimiques

Biocompatible Materials 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

213555

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Claudia Sperling (C)

Institute Biofunctional Polymer Materials, Max Bergmann Center of Biomaterials, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. Electronic address: sperling@ipfdd.de.

Manfred F Maitz (MF)

Institute Biofunctional Polymer Materials, Max Bergmann Center of Biomaterials, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. Electronic address: maitz@ipfdd.de.

Vincent Körber (V)

Institute Biofunctional Polymer Materials, Max Bergmann Center of Biomaterials, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany.

Stefanie Hänsel (S)

Institute Biofunctional Polymer Materials, Max Bergmann Center of Biomaterials, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany.

Carsten Werner (C)

Institute Biofunctional Polymer Materials, Max Bergmann Center of Biomaterials, Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Advanced in vitro hemocompatibility assessment...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Advanced in vitro hemocompatibility assessment...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Advanced in vitro hemocompatibility assessment...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Advanced in vitro hemocompatibility assessment...