Bioreactor Technologies for Enhanced Organoid Culture.
3D printing
biomimetic
differentiation
embryoid body
metabolism
pluripotent
simulated microgravity
spheroid
stem cell
stimulation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jul 2023
13 Jul 2023
Historique:
received:
15
06
2023
revised:
07
07
2023
accepted:
10
07
2023
medline:
31
7
2023
pubmed:
29
7
2023
entrez:
29
7
2023
Statut:
epublish
Résumé
An organoid is a 3D organization of cells that can recapitulate some of the structure and function of native tissue. Recent work has seen organoids gain prominence as a valuable model for studying tissue development, drug discovery, and potential clinical applications. The requirements for the successful culture of organoids in vitro differ significantly from those of traditional monolayer cell cultures. The generation and maturation of high-fidelity organoids entails developing and optimizing environmental conditions to provide the optimal cues for growth and 3D maturation, such as oxygenation, mechanical and fluidic activation, nutrition gradients, etc. To this end, we discuss the four main categories of bioreactors used for organoid culture: stirred bioreactors (SBR), microfluidic bioreactors (MFB), rotating wall vessels (RWV), and electrically stimulating (ES) bioreactors. We aim to lay out the state-of-the-art of both commercial and in-house developed bioreactor systems, their benefits to the culture of organoids derived from various cells and tissues, and the limitations of bioreactor technology, including sterilization, accessibility, and suitability and ease of use for long-term culture. Finally, we discuss future directions for improvements to existing bioreactor technology and how they may be used to enhance organoid culture for specific applications.
Identifiants
pubmed: 37511186
pii: ijms241411427
doi: 10.3390/ijms241411427
pmc: PMC10380004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NASA
ID : 80NSSC18K1480
Pays : United States
Références
Biomed Microdevices. 2017 Sep;19(3):57
pubmed: 28634847
Nature. 2013 Sep 19;501(7467):373-9
pubmed: 23995685
Nat Methods. 2012 Mar 25;9(5):509-16
pubmed: 22447133
Microorganisms. 2019 Jan 30;7(2):
pubmed: 30704141
Hepatology. 2020 Jul;72(1):257-270
pubmed: 31715015
Cell Rep Methods. 2022 Nov 15;2(11):100337
pubmed: 36452871
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2293-E2302
pubmed: 28265064
Stem Cells Transl Med. 2017 Feb;6(2):622-633
pubmed: 28191779
Biotechnol J. 2013 Mar;8(3):298-307
pubmed: 23161827
Nat Rev Cardiol. 2020 Jun;17(6):341-359
pubmed: 32015528
Lab Chip. 2018 Dec 7;18(23):3606-3616
pubmed: 30357207
Lab Chip. 2017 Jul 11;17(14):2395-2420
pubmed: 28617487
J Vis Exp. 2012 Apr 03;(62):
pubmed: 22491366
Antioxid Redox Signal. 2018 Feb 10;28(5):371-384
pubmed: 27903111
In Vitro Cell Dev Biol Anim. 1998 Apr;34(4):316-25
pubmed: 9590505
Nat Commun. 2016 Jan 19;7:10312
pubmed: 26785135
NPJ Microgravity. 2021 Jul 23;7(1):28
pubmed: 34301942
Front Mol Biosci. 2020 Mar 06;7:33
pubmed: 32211418
F1000Res. 2018 Apr 30;7:
pubmed: 29770207
Front Plant Sci. 2019 Dec 06;10:1577
pubmed: 31867033
Bioelectricity. 2021 Mar 1;3(1):27-41
pubmed: 34476376
Nat Cell Biol. 2016 Mar;18(3):246-54
pubmed: 26911908
Cell Mol Biol Lett. 2006;11(4):475-87
pubmed: 16983455
Front Nutr. 2020 Nov 04;7:575146
pubmed: 33251241
Lab Chip. 2007 Mar;7(3):302-9
pubmed: 17330160
J Cell Biochem. 1993 Mar;51(3):301-11
pubmed: 8501132
Biotechnol Bioeng. 2004 Jan 5;85(1):34-46
pubmed: 14705010
Stem Cells. 2012 May;30(5):935-45
pubmed: 22328536
Annu Rev Biomed Eng. 2000;2:377-97
pubmed: 11701517
Bioanalysis. 2012 Jun;4(12):1509-25
pubmed: 22793034
Mater Today Bio. 2022 Jul 01;16:100345
pubmed: 35847376
Nat Protoc. 2014 Oct;9(10):2329-40
pubmed: 25188634
Biotechnol Adv. 2018 Jul - Aug;36(4):1111-1126
pubmed: 29563048
Lab Chip. 2007 Oct;7(10):1238-55
pubmed: 17896006
Stem Cells Transl Med. 2021 Dec;10(12):1650-1665
pubmed: 34505405
J Tissue Eng Regen Med. 2011 Jun;5(6):e115-25
pubmed: 21604379
Lab Chip. 2006 Dec;6(12):1484-6
pubmed: 17203151
Stem Cell Res Ther. 2018 Jun 13;9(1):156
pubmed: 29895313
Sci Rep. 2018 Nov 16;8(1):16944
pubmed: 30446711
Rev Physiol Biochem Pharmacol. 2021;179:189-210
pubmed: 33619630
Biodes Manuf. 2022 Jan;5(1):43-63
pubmed: 35223131
J Neurophysiol. 2006 Jun;95(6):3311-27
pubmed: 16436479
Stem Cell Reports. 2018 Jan 9;10(1):300-313
pubmed: 29233554
Stem Cell Reports. 2019 Dec 10;13(6):960-969
pubmed: 31708475
Lab Chip. 2012 Jun 21;12(12):2165-74
pubmed: 22434367
Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C151-C165
pubmed: 32459504
Regen Med. 2018 Mar;13(2):159-173
pubmed: 29509065
Nature. 2018 Apr;556(7700):239-243
pubmed: 29618819
Cell Stem Cell. 2016 Jan 7;18(1):25-38
pubmed: 26748754
Curr Pharm Biotechnol. 2005 Oct;6(5):397-403
pubmed: 16248813
Am J Physiol Renal Physiol. 2001 Jul;281(1):F12-25
pubmed: 11399642
Biotechnol Annu Rev. 2008;14:275-96
pubmed: 18606368
Elife. 2019 Aug 27;8:
pubmed: 31451149
Tissue Eng Part C Methods. 2010 Dec;16(6):1417-26
pubmed: 20367291
BMC Dev Biol. 2019 Mar 7;19(1):3
pubmed: 30841924
Cell. 2016 May 19;165(5):1238-1254
pubmed: 27118425
Nat Commun. 2017 Apr 25;8:15112
pubmed: 28440792
Annu Rev Biomed Eng. 2017 Jun 21;19:353-387
pubmed: 28633567
Stem Cell Rev Rep. 2022 Feb;18(2):718-731
pubmed: 33725267
Biotechnol Genet Eng Rev. 2010;26:163-78
pubmed: 21415880
Nat Biotechnol. 2014 Aug;32(8):760-72
pubmed: 25093883
Nanoscale. 2016 Apr 7;8(13):7075-84
pubmed: 26960413
Nat Rev Mol Cell Biol. 2020 Oct;21(10):571-584
pubmed: 32636524
Signal Transduct Target Ther. 2022 May 24;7(1):168
pubmed: 35610212
Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H168-78
pubmed: 11123231
Nature. 2006 Jul 27;442(7101):368-73
pubmed: 16871203
Nat Protoc. 2018 Mar;13(3):565-580
pubmed: 29470464
Macromol Biosci. 2019 Jun;19(6):e1900060
pubmed: 31038841
Pharmacol Ther. 2018 Apr;184:201-211
pubmed: 29097309
Tissue Eng Part C Methods. 2016 Mar;22(3):221-49
pubmed: 26650970
Anal Chem. 2009 Jul 15;81(14):5821-6
pubmed: 19485415
Biofabrication. 2014 Mar;6(1):015009
pubmed: 24589876
PLoS One. 2019 Jul 5;14(7):e0219442
pubmed: 31276558
Circulation. 2016 Nov 15;134(20):1557-1567
pubmed: 27737958
Biomater Res. 2019 Dec 5;23:25
pubmed: 31844552
Tissue Eng Part C Methods. 2019 Aug;25(8):479-488
pubmed: 31328683
Stem Cell Res Ther. 2019 Nov 21;10(1):341
pubmed: 31753034
Biosens Bioelectron. 2015 Jan 15;63:218-231
pubmed: 25105943
J Biotechnol. 2007 May 1;129(3):421-32
pubmed: 17306403
Nat Protoc. 2006;1(4):2116-27
pubmed: 17487203
eNeuro. 2020 Aug 24;7(4):
pubmed: 32719101
Sci Adv. 2022 Aug 19;8(33):eabq5031
pubmed: 35977026
Stem Cell Res Ther. 2021 Jan 13;12(1):55
pubmed: 33436078
Sci Rep. 2018 Jun 29;8(1):9855
pubmed: 29959353
Chem Soc Rev. 2010 Mar;39(3):1036-48
pubmed: 20179823
HardwareX. 2019 Oct;6:
pubmed: 32864515
Int Orthop. 2014 Dec;38(12):2615-21
pubmed: 25030964
Science. 2018 Feb 23;359(6378):920-926
pubmed: 29472484
Biophys Rev. 2021 Sep 10;13(5):717-727
pubmed: 34765047
J Biotechnol. 2010 Nov;150(3):389-95
pubmed: 20887759