Metabolic regulation of glucagon secretion.
TCA cycle
amino acids
endocrine pancreas
fatty acids
glucose metabolism
Journal
The Journal of endocrinology
ISSN: 1479-6805
Titre abrégé: J Endocrinol
Pays: England
ID NLM: 0375363
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
received:
17
03
2023
accepted:
31
07
2023
medline:
11
9
2023
pubmed:
31
7
2023
entrez:
31
7
2023
Statut:
epublish
Résumé
Since the discovery of glucagon 100 years ago, the hormone and the pancreatic islet alpha cells that produce it have remained enigmatic relative to insulin-producing beta cells. Canonically, alpha cells have been described in the context of glucagon's role in glucose metabolism in liver, with glucose as the primary nutrient signal regulating alpha cell function. However, current data reveal a more holistic model of metabolic signalling, involving glucagon-regulated metabolism of multiple nutrients by the liver and other tissues, including amino acids and lipids, providing reciprocal feedback to regulate glucagon secretion and even alpha cell mass. Here we describe how various nutrients are sensed, transported and metabolised in alpha cells, providing an integrative model for the metabolic regulation of glucagon secretion and action. Importantly, we discuss where these nutrient-sensing pathways intersect to regulate alpha cell function and highlight key areas for future research.
Identifiants
pubmed: 37523232
doi: 10.1530/JOE-23-0081
pii: e230081
pmc: PMC10681275
mid: NIHMS1926803
doi:
pii:
Substances chimiques
Glucagon
9007-92-5
Glucose
IY9XDZ35W2
Insulin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK132669
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117147
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK134158
Pays : United States
Organisme : Medical Research Council
ID : MR/W019590/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK130296
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
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