Discovery of 1,3-disubstituted pyrazole peripheral cannabinoid receptor partial agonists.

Cannabinoid Receptor Agonists / pharmacology Tissue Distribution Dronabinol Pyrazoles / pharmacology Receptors, Cannabinoid Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2
Agonist CB1 CB2 Cannabinoid Compound Peripheral

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
01 09 2023
Historique:
received: 17 02 2023
revised: 13 07 2023
accepted: 31 07 2023
pmc-release: 01 09 2024
medline: 21 8 2023
pubmed: 6 8 2023
entrez: 5 8 2023
Statut: ppublish

Résumé

Partial agonists of peripheral cannabinoid receptors (CBRs) have potential therapeutic applications in several medical conditions. However, (-)-trans-Δ

Identifiants

DOI: 10.1016/j.bmcl.2023.129430 PMID: 37543275 PMC: PMC10529378
pubmed: 37543275
pii: S0960-894X(23)00308-6
doi: 10.1016/j.bmcl.2023.129430
pmc: PMC10529378
mid: NIHMS1923600
pii:
doi:

Substances chimiques

Cannabinoid Receptor Agonists 0
Dronabinol 7J8897W37S
Pyrazoles 0
Receptors, Cannabinoid 0
Receptor, Cannabinoid, CB1 0
Receptor, Cannabinoid, CB2 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

129430

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA040460
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124615
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Références

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Auteurs

George Amato (G)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.

Scott Runyon (S)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.

Vineetha Vasukuttan (V)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.

Ann M Decker (AM)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.

Elaine A Gay (EA)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.

Lucas Laudermilk (L)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.

Rangan Maitra (R)

Discovery Sciences, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA. Electronic address: rmaitra@rti.org.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Modulateurs des récepteurs de cannabinoïdes › Agonistes des récepteurs de cannabinoïdes › Discovery of 1,3-disubstituted pyrazole...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Discovery of 1,3-disubstituted pyrazole...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Cannabinoïdes › Dronabinol › Discovery of 1,3-disubstituted pyrazole...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Discovery of 1,3-disubstituted pyrazole...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Discovery of 1,3-disubstituted pyrazole...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB1 › Discovery of 1,3-disubstituted pyrazole...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs de cannabinoïdes › Récepteur cannabinoïde de type CB2 › Discovery of 1,3-disubstituted pyrazole...