Vasoplegia: A Review.
catecholamines
septic shock
vasodilatory shock
vasoplegia
vasopressors
Journal
Methodist DeBakey cardiovascular journal
ISSN: 1947-6108
Titre abrégé: Methodist Debakey Cardiovasc J
Pays: United States
ID NLM: 101508600
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
04
2023
accepted:
03
05
2023
medline:
8
8
2023
pubmed:
7
8
2023
entrez:
7
8
2023
Statut:
epublish
Résumé
Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure, sepsis, and post-cardiac surgery. In the cardiac cohort, multiple risk factors for vasoplegia have been identified. Several factors contribute to the pathophysiology of this condition, and various mechanisms have been proposed, including nitric oxide, adenosine, prostanoids, endothelins, the renin-angiotensin-aldosterone system, and hydrogen sulfide. Early identification and prompt management of vasoplegia is crucial to prevent development of shock. This review expands upon the different vasopressors used in management of vasoplegia, including catecholamines such as norepinephrine, dopamine, epinephrine, phenylephrine, and other agents including vasopressin, methylene blue, angiotensin II, hydroxocobalamin, vitamin C, thiamine, and corticosteroids (ie, hydrocortisone). It also emphasizes the importance of conducting further research and making advancements in treatment regimens for vasoplegia.
Identifiants
pubmed: 37547893
doi: 10.14797/mdcvj.1245
pmc: PMC10402787
doi:
Substances chimiques
Epinephrine
YKH834O4BH
Norepinephrine
X4W3ENH1CV
Phenylephrine
1WS297W6MV
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-47Informations de copyright
Copyright: © 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors have no competing interests to declare.
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