Unraveling allostery within the angiotensin II type 1 receptor for Gα
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
08 08 2023
08 08 2023
Historique:
medline:
10
8
2023
pubmed:
8
8
2023
entrez:
8
8
2023
Statut:
ppublish
Résumé
G protein-coupled receptors engage both G proteins and β-arrestins, and their coupling can be biased by ligands and mutations. Here, to resolve structural elements and mechanisms underlying effector coupling to the angiotensin II (AngII) type 1 receptor (AT1R), we combined alanine scanning mutagenesis of the entire sequence of the receptor with pharmacological profiling of Gα
Identifiants
pubmed: 37552769
doi: 10.1126/scisignal.adf2173
pmc: PMC10640921
mid: NIHMS1933204
doi:
Substances chimiques
beta-Arrestins
0
Receptor, Angiotensin, Type 1
0
beta-Arrestin 1
0
GTP-Binding Proteins
EC 3.6.1.-
Angiotensin II
11128-99-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadf2173Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM117923
Pays : United States
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