2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery.

Humans Receptor, Serotonin, 5-HT2B Serotonin Fenfluramine Heart Valve Diseases Drug Discovery

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
24 08 2023
Historique:
medline: 25 8 2023
pubmed: 16 8 2023
entrez: 16 8 2023
Statut: ppublish

Résumé

The cardiotoxicity associated with

Identifiants

DOI: 10.1021/acs.jmedchem.3c01178 PMID: 37584406
pubmed: 37584406
doi: 10.1021/acs.jmedchem.3c01178
doi:

Substances chimiques

Receptor, Serotonin, 5-HT2B 0
Serotonin 333DO1RDJY
Fenfluramine 2DS058H2CF

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

11027-11039

Subventions

Organisme : NICHD NIH HHS
ID : P50 HD103537
Pays : United States

Auteurs

Aaron M Bender (AM)

Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
ORCID: 0000-0003-0432-1648

Lauren C Parr (LC)

Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

William B Livingston (WB)

Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37240, United States.
ORCID: 0009-0007-6696-7117

Craig W Lindsley (CW)

Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232, United States.
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.
Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States.
Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.
ORCID: 0000-0003-0168-1445

W David Merryman (WD)

Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37240, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › 2B Determined: The Future of the Serotonin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Récepteurs de la sérotonine de type 5-HT2 › Récepteur de la sérotonine de type 5-HT2B › 2B Determined: The Future of the Serotonin...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › 2B Determined: The Future of the Serotonin...
questionsmedicales.fr › Composés chimiques organiques › Amines › Éthylamines › Phénéthylamines › Fenfluramine › 2B Determined: The Future of the Serotonin...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Valvulopathies › 2B Determined: The Future of the Serotonin...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › 2B Determined: The Future of the Serotonin...