Glutarate regulates T cell metabolism and anti-tumour immunity.
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
31
10
2022
accepted:
03
07
2023
medline:
26
10
2023
pubmed:
22
8
2023
entrez:
21
8
2023
Statut:
ppublish
Résumé
T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets. We show here that glutarate, a product of amino acid catabolism, has the capacity to do both, and has potent effects on T cell function and differentiation. We found that glutarate exerts those effects both through α-ketoglutarate-dependent dioxygenase inhibition, and through direct regulation of T cell metabolism via glutarylation of the pyruvate dehydrogenase E2 subunit. Administration of diethyl glutarate, a cell-permeable form of glutarate, alters CD8
Identifiants
pubmed: 37605057
doi: 10.1038/s42255-023-00855-2
pii: 10.1038/s42255-023-00855-2
pmc: PMC10590756
doi:
Substances chimiques
Glutarates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1747-1764Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 214283/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 215477/Z/19/Z
Pays : United Kingdom
Informations de copyright
© 2023. The Author(s).
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