Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1

T Cell Transcription Factor 1 / genetics CD28 Antigens Programmed Cell Death 1 Receptor CD8-Positive T-Lymphocytes Cell Differentiation Transcription Factors

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
04 08 2023
Historique:
medline: 28 8 2023
pubmed: 25 8 2023
entrez: 25 8 2023
Statut: ppublish

Résumé

During persistent antigen stimulation, such as in chronic infections and cancer, CD8 T cells differentiate into a hypofunctional programmed death protein 1-positive (PD-1

Identifiants

DOI: 10.1126/sciimmunol.adg0878 PMID: 37624910
pubmed: 37624910
doi: 10.1126/sciimmunol.adg0878
doi:

Substances chimiques

T Cell Transcription Factor 1 0
CD28 Antigens 0
Programmed Cell Death 1 Receptor 0
Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg0878

Subventions

Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153363
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154683
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA271346
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA237264
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA267696
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA263705
Pays : United States

Auteurs

Etienne Humblin (E)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0000-0002-4559-6106

Isabel Korpas (I)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0009-0005-5392-6960

Jiahua Lu (J)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0000-0001-8544-891X

Dan Filipescu (D)

Department of Oncological Sciences, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0001-6381-2557

Verena van der Heide (V)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0000-0002-3602-4405

Simon Goldstein (S)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0009-0008-1259-4017

Abishek Vaidya (A)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0000-0001-8458-7950

Alessandra Soares-Schanoski (A)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0000-0002-6514-8458

Beatrice Casati (B)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
ORCID: 0000-0001-8516-5792

Myvizhi E Selvan (ME)

Department of Genetics and Genomics, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0003-4640-5727

Zeynep H Gümüş (ZH)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Department of Genetics and Genomics, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0002-7364-2202

Andreas Wieland (A)

Department of Otolaryngology-Head and Neck Surgery and Pelotonia Institute for Immuno-Oncology, OSUCCC-James, Ohio State University, Columbus, OH 43210, USA.
ORCID: 0000-0001-9648-7922

Mauro Corrado (M)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine (CMMC) and Institute for Genetics, University of Cologne, 50931 Cologne, Germany.
ORCID: 0000-0002-0617-3274

Leona Cohen-Gould (L)

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10029, USA.
ORCID: 0000-0001-7081-7268

Emily Bernstein (E)

Department of Oncological Sciences, ISMMS, New York, NY 10029, USA.
Tisch Cancer Institute, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0001-6533-8326

Dirk Homann (D)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Diabetes Obesity Metabolism Institute, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0002-7622-5754

Jerry Chipuk (J)

Department of Oncological Sciences, ISMMS, New York, NY 10029, USA.
Tisch Cancer Institute, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0002-1337-842X

Alice O Kamphorst (AO)

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
Department of Oncological Sciences, ISMMS, New York, NY 10029, USA.
Tisch Cancer Institute, ISMMS, New York, NY 10029, USA.
ORCID: 0000-0002-9230-9501

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription TCF › Facteur de transcription TCF-1 › Sustained CD28 costimulation is required for...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CD28 › Sustained CD28 costimulation is required for...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Sustained CD28 costimulation is required for...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Sustained CD28 costimulation is required for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Sustained CD28 costimulation is required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Sustained CD28 costimulation is required for...