Mutations of
BRCA1
BRCA2
CNA
DNA copy number aberrations
PALB2
efficiency
mutations
neoadjuvant chemotherapy
prognosis
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
28 07 2023
28 07 2023
Historique:
received:
19
06
2023
revised:
24
07
2023
accepted:
26
07
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
It has been shown that the loss of function of the The study included 66 patients with breast cancer. DNA copy number aberrations (CNA) were assessed by high-density CytoScanHD™ Array micro matrix analysis. Gene mutations were assessed by sequencing on the MiSeq™ Sequencing System using the Accel-Amplicon It has been established that the presence of a normal copy number of Currently, there is little data on the effect of chromosomal aberrations and mutations in the BRCA1/2 and PALB2 genes on the effectiveness of treatment and prognosis of the disease. At the same time, the study of these genes has great potential for testing focused on a personalized approach to the treatment of patients with breast cancer.
Identifiants
pubmed: 37628606
pii: genes14081554
doi: 10.3390/genes14081554
pmc: PMC10454606
pii:
doi:
Substances chimiques
BRCA2 protein, human
0
BRCA2 Protein
0
BRCA1 protein, human
0
BRCA1 Protein
0
PALB2 protein, human
0
Fanconi Anemia Complementation Group N Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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