Fluorosulfate as a Latent Sulfate in Peptides and Proteins.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
20 09 2023
20 09 2023
Historique:
pmc-release:
20
09
2024
medline:
21
9
2023
pubmed:
30
8
2023
entrez:
30
8
2023
Statut:
ppublish
Résumé
Sulfation widely exists in the eukaryotic proteome. However, understanding the biological functions of sulfation in peptides and proteins has been hampered by the lack of methods to control its spatial or temporal distribution in the proteome. Herein, we report that fluorosulfate can serve as a latent precursor of sulfate in peptides and proteins, which can be efficiently converted to sulfate by hydroxamic acid reagents under physiologically relevant conditions. Photocaging the hydroxamic acid reagents further allowed for the light-controlled activation of functional sulfopeptides. This work provides a valuable tool for probing the functional roles of sulfation in peptides and proteins.
Identifiants
pubmed: 37647087
doi: 10.1021/jacs.3c07937
pmc: PMC10623540
mid: NIHMS1939021
doi:
Substances chimiques
Proteome
0
Sulfates
0
Peptides
0
Hydroxamic Acids
0
Sulfur Oxides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20189-20195Subventions
Organisme : NHGRI NIH HHS
ID : DP2 HG011027
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136437
Pays : United States
Organisme : NIH HHS
ID : S10 OD026910
Pays : United States
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