Can Genome Sequencing Coupled to Flux Balance Analyses Offer Precision Guidance for Industrial Strain Development? The Lessons from Carbon Trafficking in

Corynebacterium glutamicum / genetics Chromosome Mapping Industry Carbon
Corynebacterium glutamicum carbon trafficking flux balance analysis genome sequencing industrial strain development l-tyrosine overproduction

Journal

Omics : a journal of integrative biology
ISSN: 1557-8100
Titre abrégé: OMICS
Pays: United States
ID NLM: 101131135

Informations de publication

Date de publication:
09 2023
Historique:
medline: 18 9 2023
pubmed: 14 9 2023
entrez: 14 9 2023
Statut: ppublish

Résumé

Systems biology tools offer new prospects for industrial strain selection. For bacteria that are significant for industrial applications, whole-genome sequencing coupled to flux balance analysis (FBA) can help unpack the complex relationships between genome mutations and carbon trafficking. This work investigates the l-tyrosine (l-Tyr) overproducing model system

Identifiants

DOI: 10.1089/omi.2023.0098 PMID: 37707996
pubmed: 37707996
doi: 10.1089/omi.2023.0098
doi:

Substances chimiques

shikimate 0
Carbon 7440-44-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

434-443

Auteurs

Eldin Kurpejović (E)

Department of Bioengineering, Marmara University, Istanbul, Turkey.

Daniel Wibberg (D)

Genome Research of Industrial Microorganisms, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.

Gülsüm Merve Bastem (GM)

Department of Bioengineering, Marmara University, Istanbul, Turkey.

Arthur Burgardt (A)

Genetics of Prokaryotes, Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.

Tobias Busche (T)

Technology Platform Genomics, Center for Biotechnology, Bielefeld University, Bielefeld, Germany.
Medical School East Westphalia-Lippe, Bielefeld University, Bielefeld, Germany.

Fatma Ece Altinisik Kaya (FEA)

Department of Bioengineering, Marmara University, Istanbul, Turkey.
Department of Computer Science, Eberhard Karl University of Tübingen, Tübingen, Germany.

Andreas Dräger (A)

Department of Computer Science, Eberhard Karl University of Tübingen, Tübingen, Germany.
Computational Systems Biology of Infections and Antimicrobial-Resistant Pathogens, Institute for Bioinformatics and Medical Informatics (IBMI), Eberhard Karl University of Tübingen, Tübingen, Germany.

Volker F Wendisch (VF)

Genetics of Prokaryotes, Faculty of Biology, Bielefeld University, Bielefeld, Germany.
Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.

Berna Sariyar Akbulut (BS)

Department of Bioengineering, Marmara University, Istanbul, Turkey.
ORCID: 0000-0002-4455-1192

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes irréguliers à Gram positif › Corynebacterium › Corynebacterium glutamicum › Can Genome Sequencing Coupled to Flux Balance...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Cartographie chromosomique › Can Genome Sequencing Coupled to Flux Balance...
questionsmedicales.fr › Technologie, industrie et agriculture › Industrie › Can Genome Sequencing Coupled to Flux Balance...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Carbone › Can Genome Sequencing Coupled to Flux Balance...