A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases.

Methyltransferases / genetics Alkylation Biocatalysis Engineering Keto Acids Methenamine Pseudomonas aeruginosa / genetics

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
14 09 2023
Historique:
received: 27 07 2023
accepted: 17 08 2023
medline: 18 9 2023
pubmed: 15 9 2023
entrez: 14 9 2023
Statut: epublish

Résumé

Catalytic asymmetric α-alkylation of carbonyl compounds represents a long-standing challenge in synthetic organic chemistry. Herein, we advance a dual biocatalytic platform for the efficient asymmetric alkylation of α-keto acids. First, guided by our recently obtained crystal structures, we develop SgvM

Identifiants

DOI: 10.1038/s41467-023-40980-w PMID: 37709735 PMC: PMC10502145
pubmed: 37709735
doi: 10.1038/s41467-023-40980-w
pii: 10.1038/s41467-023-40980-w
pmc: PMC10502145
doi:

Substances chimiques

Methyltransferases EC 2.1.1.-
Keto Acids 0
Methenamine J50OIX95QV

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

5704

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Shuyun Ju (S)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.
ORCID: 0000-0002-0322-104X

Kaylee P Kuzelka (KP)

Department of Biochemistry, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Rui Guo (R)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.

Benjamin Krohn-Hansen (B)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.
ORCID: 0000-0003-3498-0660

Jianping Wu (J)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.

Satish K Nair (SK)

Department of Biochemistry, Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. snair@illinois.edu.
Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. snair@illinois.edu.
ORCID: 0000-0003-1790-1334

Yang Yang (Y)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA. yang@chem.ucsb.edu.
Biomolecular Science and Engineering (BMSE) Program, University of California, Santa Barbara, CA, USA. yang@chem.ucsb.edu.
ORCID: 0000-0002-4956-2034

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › A biocatalytic platform for asymmetric...
questionsmedicales.fr › Métabolisme › Alkylation › A biocatalytic platform for asymmetric...
questionsmedicales.fr › Métabolisme › Biocatalyse › A biocatalytic platform for asymmetric...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › A biocatalytic platform for asymmetric...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › A biocatalytic platform for asymmetric...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Méthénamine › A biocatalytic platform for asymmetric...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › A biocatalytic platform for asymmetric...