Spo13/MEIKIN ensures a Two-Division meiosis by preventing the activation of APC/C
Spo13/MEIKIN
cyclin phosphorylation
meiotic exit
polo-like kinase
translational repression
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
16 10 2023
16 10 2023
Historique:
revised:
03
09
2023
received:
14
04
2023
accepted:
04
09
2023
medline:
23
10
2023
pubmed:
20
9
2023
entrez:
20
9
2023
Statut:
ppublish
Résumé
Genome haploidization at meiosis depends on two consecutive nuclear divisions, which are controlled by an oscillatory system consisting of Cdk1-cyclin B and the APC/C bound to the Cdc20 activator. How the oscillator generates exactly two divisions has been unclear. We have studied this question in yeast where exit from meiosis involves accumulation of the APC/C activator Ama1 at meiosis II. We show that inactivation of the meiosis I-specific protein Spo13/MEIKIN results in a single-division meiosis due to premature activation of APC/C
Identifiants
pubmed: 37728253
doi: 10.15252/embj.2023114288
pmc: PMC10577557
doi:
Substances chimiques
Anaphase-Promoting Complex-Cyclosome
EC 2.3.2.27
Saccharomyces cerevisiae Proteins
0
Cell Cycle Proteins
0
Cdc20 Proteins
0
Ama1 protein, S cerevisiae
0
Rim4 protein, S cerevisiae
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e114288Informations de copyright
© 2023 The Authors. Published under the terms of the CC BY 4.0 license.
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