Reductive carboxylation epigenetically instructs T cell differentiation.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
08
01
2022
accepted:
15
08
2023
medline:
5
10
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
Protective immunity against pathogens or cancer is mediated by the activation and clonal expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid proliferation and effector functions, naive T cells switch their quiescent metabolism to an anabolic metabolism through increased levels of aerobic glycolysis, but also through mitochondrial metabolism and oxidative phosphorylation, generating energy and signalling molecules
Identifiants
pubmed: 37730993
doi: 10.1038/s41586-023-06546-y
pii: 10.1038/s41586-023-06546-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
849-856Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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