Reductive carboxylation epigenetically instructs T cell differentiation.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Sep 2023
Historique:
received: 08 01 2022
accepted: 15 08 2023
medline: 5 10 2023
pubmed: 21 9 2023
entrez: 21 9 2023
Statut: ppublish

Résumé

Protective immunity against pathogens or cancer is mediated by the activation and clonal expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid proliferation and effector functions, naive T cells switch their quiescent metabolism to an anabolic metabolism through increased levels of aerobic glycolysis, but also through mitochondrial metabolism and oxidative phosphorylation, generating energy and signalling molecules

Identifiants

pubmed: 37730993
doi: 10.1038/s41586-023-06546-y
pii: 10.1038/s41586-023-06546-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

849-856

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Alison Jaccard (A)

Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.

Tania Wyss (T)

Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Translational Data Science (TDS) Group, AGORA Cancer Research Center, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland.

Noelia Maldonado-Pérez (N)

Department of Genomic Medicine, Pfizer-University of Granada-Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Granada, Spain.

Jan A Rath (JA)

Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.
Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Léman, Lausanne, Switzerland.

Alessio Bevilacqua (A)

Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.

Jhan-Jie Peng (JJ)

Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.
Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.

Anouk Lepez (A)

AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Léman, Lausanne, Switzerland.
Brain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland.

Christine Von Gunten (C)

Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.
Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Léman, Lausanne, Switzerland.

Fabien Franco (F)

Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.

Kung-Chi Kao (KC)

Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.

Nicolas Camviel (N)

Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.
Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.

Francisco Martín (F)

Department of Genomic Medicine, Pfizer-University of Granada-Junta de Andalucía, Centre for Genomics and Oncological Research (GENYO), Granada, Spain.

Bart Ghesquière (B)

Metabolomics Expertise Center, Center for Cancer Biology, VIB, KU Leuven, Leuven, Belgium.
Laboratory of Applied Mass Spectrometry, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Denis Migliorini (D)

AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Léman, Lausanne, Switzerland.
Brain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland.
Department of Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland.

Caroline Arber (C)

Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland.
Department of Oncology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
AGORA Cancer Research Center, Lausanne, Switzerland.
Swiss Cancer Center Léman, Lausanne, Switzerland.

Pedro Romero (P)

Department of Oncology, University of Lausanne, Lausanne, Switzerland. pedro.romero@unil.ch.

Ping-Chih Ho (PC)

Department of Oncology, University of Lausanne, Lausanne, Switzerland. ping-chih.ho@unil.ch.
Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Épalinges, Switzerland. ping-chih.ho@unil.ch.

Mathias Wenes (M)

Department of Oncology, University of Lausanne, Lausanne, Switzerland. mathias.wenes@unige.ch.
AGORA Cancer Research Center, Lausanne, Switzerland. mathias.wenes@unige.ch.
Swiss Cancer Center Léman, Lausanne, Switzerland. mathias.wenes@unige.ch.
Brain Tumor and Immune Cell Engineering Group, Faculty of Medicine, University of Geneva, Geneva, Switzerland. mathias.wenes@unige.ch.
Center for Translational Research in Onco-Hematology, University of Geneva, Geneva, Switzerland. mathias.wenes@unige.ch.

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