Kinetic study on the reaction of sodium nitrite with neurotransmitters secreted in the stomach.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 09 2023
21 09 2023
Historique:
received:
24
01
2023
accepted:
14
09
2023
medline:
25
9
2023
pubmed:
22
9
2023
entrez:
21
9
2023
Statut:
epublish
Résumé
Nitroso-compounds are potentially mutagenic and carcinogenic compounds due to their ability to alkylate DNA bases. One of the most common sources of human exposure to nitroso-compounds is their formation in the acidic environment of the stomach by the reaction between electron-rich molecules present in the lumen and sodium nitrite ingested in the diet. To date, the formation of nitroso-compounds by the reaction of nitrite with food components has been investigated in depth, but little attention has been paid to substances secreted in the stomach, such as dopamine or serotonin, whose reaction products with nitrite have proven mutagenic properties. In this article, we present a kinetic study with UV-visible spectroscopy of the nitrosation reactions of both molecules, as well as of L-tyrosine, the amino-acid precursor of dopamine. We determined the kinetic parameters and reaction mechanisms for the reactions, studying the influence of the reactants concentration, pH, temperature, and ionic strength on the reaction rate. In all cases, the favoured reaction product was a stable nitroso-compound. Serotonin, the molecule whose product was the most mutagenic, underwent two consecutive nitrosation reactions. These findings suggest that additional biological research is needed to understand how this reaction alters the function of these neurotransmitters as well as the potentially toxic effects they may have once nitrosated.
Identifiants
pubmed: 37735226
doi: 10.1038/s41598-023-42759-x
pii: 10.1038/s41598-023-42759-x
pmc: PMC10514311
doi:
Substances chimiques
Sodium Nitrite
M0KG633D4F
Dopamine
VTD58H1Z2X
Serotonin
333DO1RDJY
Nitroso Compounds
0
Neurotransmitter Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15713Informations de copyright
© 2023. Springer Nature Limited.
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