Mitochondrial-Derived Vesicles: The Good, the Bad, and the Ugly.
damage-associated molecular patterns (DAMPs)
endosomal–lysosomal system
exosomes
extracellular vesicles
inflammation
mitochondrial DNA
mitochondrial quality control
mitophagy
mitovesicles
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Sep 2023
08 Sep 2023
Historique:
received:
08
08
2023
revised:
01
09
2023
accepted:
06
09
2023
medline:
29
9
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is challenging. The endosomal-lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles (EVs), which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into EVs occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles (MDVs), cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity. Both positive and negative effects of EVs on recipient cells have been described. Whether this is due to the production of EVs other than those containing mitochondria, such as MDVs, holding specific biological functions is currently unknown. Evidence on the existence of different MDV subtypes has been produced. However, their characterization is not always pursued, which would be relevant to exploring the dynamics of mitochondrial quality control in health and disease. Furthermore, MDV classification may be instrumental in understanding their biological roles and promoting their implementation as biomarkers in clinical studies.
Identifiants
pubmed: 37762138
pii: ijms241813835
doi: 10.3390/ijms241813835
pmc: PMC10531235
pii:
doi:
Substances chimiques
Alarmins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Catholic University of the Sacred Heart
ID : D1.2020
Organisme : Catholic University of the Sacred Heart
ID : D1.2022
Organisme : Catholic University of the Sacred Heart
ID : D1.2023
Organisme : Centro Studi Achille e Linda Lorenzon
ID : N/A
Organisme : Ministero della Salute
ID : Ricerca Corrente 2023
Organisme : Ministero della Salute
ID : Progetto della rete degli IRCCS Aging R.C.R. 2022
Organisme : Italian Association for Cancer Research
ID : IG 2021 - ID. 25795
Organisme : Next Generation EU
ID : DM 1557 11.10.2022
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