The Mechanism of Inhibition of Pyruvate Formate Lyase by Methacrylate.

Methacrylates Free Radicals / metabolism Acetyltransferases / metabolism Escherichia coli / metabolism Cysteine / chemistry Pyruvates Formates Lyases

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
18 10 2023
Historique:
medline: 23 10 2023
pubmed: 5 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

Pyruvate Formate Lyase (PFL) catalyzes acetyl transfer from pyruvate to coenzyme a by a mechanism involving multiple amino acid radicals. A post-translationally installed glycyl radical (G

Identifiants

DOI: 10.1021/jacs.3c07256 PMID: 37797332 PMC: PMC10591478
pubmed: 37797332
doi: 10.1021/jacs.3c07256
pmc: PMC10591478
doi:

Substances chimiques

Methacrylates 0
Free Radicals 0
Acetyltransferases EC 2.3.1.-
Cysteine K848JZ4886
Pyruvates 0
Formates 0
Lyases EC 4.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

22504-22515

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Auteurs

Juan Carlos Cáceres (JC)

Biomolecular Science and Engineering Program, University of California, Santa Barbara, California 93106, United States.

August Dolmatch (A)

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.

Brandon L Greene (BL)

Biomolecular Science and Engineering Program, University of California, Santa Barbara, California 93106, United States.
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
ORCID: 0000-0001-6981-5900

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acrylates › Méthacrylates › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Pyruvates › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Formiates › The Mechanism of Inhibition of Pyruvate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › The Mechanism of Inhibition of Pyruvate...