Rapid ultra-sensitive nucleic acid detection using plasmonic fiber-optic spectral combs and gold nanoparticle-tagged targets.

Gold / chemistry Biosensing Techniques Metal Nanoparticles / chemistry Fiber Optic Technology Surface Plasmon Resonance
Gold nanoparticle-tagged Nucleic acid Plasmonic fiber-optic spectral combs Ultra-low detection limit

Journal

Biosensors & bioelectronics
ISSN: 1873-4235
Titre abrégé: Biosens Bioelectron
Pays: England
ID NLM: 9001289

Informations de publication

Date de publication:
15 Dec 2023
Historique:
received: 19 02 2023
revised: 24 08 2023
accepted: 28 09 2023
medline: 30 10 2023
pubmed: 6 10 2023
entrez: 5 10 2023
Statut: ppublish

Résumé

Nucleic acid (NA) is a widely-used biomarker for viruses. Accurate quantification of NA can provide a reliable basis for point-of-care diagnosis and treatment. Here, we propose a tilted fiber Bragg grating (TFBG)-based plasmonic fiber-optic spectral comb for fast response and ultralow limit NA detection. The TFBG is coated with a gold film which enables excitation of surface plasmon resonance (SPR), and single-stranded probe NAs with known base sequences are assembled on the gold film. To enhance sensitivity of refractive index (RI) for sensing a chosen combination of probe and target NAs around the TFBG surface, gold nanoparticles (AuNPs) are bonded to the target NA molecules as "RI-labels". The NA combination-induced aggregation of AuNPs induces significant spectral responses in the TFBG that would be below the detection threshold for the NAs in the absence of the AuNPs. The proposed TFBG-SPR NA sensor shows a fast response time of 30 s and an ultra-wide NA detection range from 1 × 10

Identifiants

DOI: 10.1016/j.bios.2023.115719 PMID: 37797532
pubmed: 37797532
pii: S0956-5663(23)00661-9
doi: 10.1016/j.bios.2023.115719
pii:
doi:

Substances chimiques

Gold 7440-57-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115719

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Changyu Shen (C)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China. Electronic address: shenchangyu@cjlu.edu.cn.

Zhenlin Huang (Z)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Xiaoman Chen (X)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Zhihao Wang (Z)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Jun Zhou (J)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Zhaokun Wang (Z)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Dejun Liu (D)

Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.

Chenxia Li (C)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Tianqi Zhao (T)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Yang Zhang (Y)

School of Physics, Dalian University of Technology, Dalian, Liaoning, 116024, China.

Shiqing Xu (S)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Wenjun Zhou (W)

College of Optical and Electronic Technology, China Jiliang University, Hangzhou, Zhejiang, 310018, China.

Wei Peng (W)

School of Physics, Dalian University of Technology, Dalian, Liaoning, 116024, China.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › Rapid ultra-sensitive nucleic acid detection...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Rapid ultra-sensitive nucleic acid detection...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Rapid ultra-sensitive nucleic acid detection...
questionsmedicales.fr › Disciplines des sciences naturelles › Physique › Technologie des fibres optiques › Rapid ultra-sensitive nucleic acid detection...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Résonance plasmonique de surface › Rapid ultra-sensitive nucleic acid detection...