Hierarchical Fluid Interface Enables Spatiotemporal Regulation of Ligand Distribution to Increase Kinetics and Thermodynamics of Interfacial Binding Reaction.
Hierarchical Fluid Interface
Kinetics
Ligand Recruitment
Microfluidics
Thermodynamics
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
04 Dec 2023
04 Dec 2023
Historique:
received:
29
08
2023
medline:
29
11
2023
pubmed:
19
10
2023
entrez:
19
10
2023
Statut:
ppublish
Résumé
In nature, regulation of the spatiotemporal distribution of interfacial receptors and ligands leads to optimum binding kinetics and thermodynamics of receptor-ligand binding reactions within interfaces. Inspired by this, we report a hierarchical fluid interface (HieFluidFace) to regulate the spatiotemporal distribution of interfacial ligands to increase the rate and thermodynamic favorability of interfacial binding reactions. Each aptamer-functionalized gold nanoparticle, termed spherical aptamer (SAPT), is anchored on a supported lipid bilayer without fluidity, like an "island", and is surrounded by many fluorescent aptamers (FAPTs) with free fluidity, like "rafts". Such ligand "island-rafts" model provides a large reactive cross-section for rapid binding to cellular receptors. The synergistic multivalency of SAPTs and FAPTs improves interfacial affinity for tight capture. Moreover, FAPTs accumulate at binding sites to bind to cellular receptors with clustered fluorescence to "lighten" cells for direct identification. Thus, HieFluidFace in a microfluidic chip achieves high-performance capture and identification of circulating tumor cells from clinical samples, providing a new paradigm to optimize the kinetics and thermodynamics of interfacial binding reactions.
Identifiants
pubmed: 37853512
doi: 10.1002/anie.202312581
doi:
Substances chimiques
Ligands
0
Gold
7440-57-5
Receptors, Cell Surface
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202312581Subventions
Organisme : National Natural Science Foundation of China
ID : 22004083
Organisme : National Natural Science Foundation of China
ID : 21927806
Organisme : National Natural Science Foundation of China
ID : 22293031
Organisme : National Natural Science Foundation of China
ID : 82227801
Organisme : Innovative research team of high-level local universities in Shanghai
ID : SHSMU-ZLCX20212601
Organisme : National Key R&D Program of China
ID : 2019YFA0905800
Informations de copyright
© 2023 Wiley-VCH GmbH.
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