Optimization of degradation behavior and conditions for the protease K of polylactic acid films by simulation.

Endopeptidase K Molecular Docking Simulation Polyesters / metabolism Biodegradable Plastics Plastics
Enzymatic degradation Molecular docking Molecular dynamics simulation Polylactic acid films Protease K

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Dec 2023
Historique:
received: 24 08 2023
revised: 09 10 2023
accepted: 15 10 2023
medline: 27 11 2023
pubmed: 20 10 2023
entrez: 20 10 2023
Statut: ppublish

Résumé

With global enforcement of plastic bans and restrictions, the biodegradable plastic, e.g., polylactic acid (PLA), has been extensively employed as a primary substitute for traditional petroleum-based plastics. However, the growing problem associated with PLA waste accumulation is posing grand environmental challenges. In addition, although PLA has the degrading property under natural conditions, the degradation process takes too long and the degradation products cannot be recycled. In this context, enzymatic degradation of PLA arouses great attention in scientific communities. This study aims at selecting the most cost-effective protease from various enzymes and optimizing the enzymolysis conditions towards the degradation of PLA. We will demonstrate that under an optimal temperature of 45 °C, a pH vale of 11, and an enzyme concentration of 0.6 mg mL

Identifiants

DOI: 10.1016/j.ijbiomac.2023.127496 PMID: 37858641
pubmed: 37858641
pii: S0141-8130(23)04393-3
doi: 10.1016/j.ijbiomac.2023.127496
pii:
doi:

Substances chimiques

poly(lactide) 459TN2L5F5
Endopeptidase K EC 3.4.21.64
Polyesters 0
Biodegradable Plastics 0
Plastics 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

127496

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Wenlong Pang (W)

Institute of Circular Economy, Beijing University of Technology, Beijing, 100022, China; Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing, 100022, China; State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Bin Li (B)

Institute of Circular Economy, Beijing University of Technology, Beijing, 100022, China; Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing, 100022, China.

Yufeng Wu (Y)

Institute of Circular Economy, Beijing University of Technology, Beijing, 100022, China; Faculty of Materials and Manufacturing, Beijing University of Technology, Beijing, 100022, China. Electronic address: wuyufeng3r@126.com.

Shaonan Tian (S)

State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Yu Zhang (Y)

State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Jun Yang (J)

State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Endopeptidase K › Optimization of degradation behavior and...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Optimization of degradation behavior and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Optimization of degradation behavior and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Matières plastiques biodégradables › Optimization of degradation behavior and...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Optimization of degradation behavior and...