Assessing the Potential of Small Peptides for Altering Expression Levels of the Iron-Regulatory Genes
FTH1 modulation
anticancer peptides
bioactive oligopeptides
chemosensitization
iron metabolism
iron regulating peptides
prostate cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Oct 2023
16 Oct 2023
Historique:
received:
30
08
2023
revised:
05
10
2023
accepted:
10
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Recent research highlights the key role of iron dyshomeostasis in the pathogenesis of prostate cancer (PCa). PCa cells are heavily dependent on bioavailable iron, which frequently results in the reprogramming of iron uptake and storage pathways. Although advanced-stage PCa is currently incurable, bioactive peptides capable of modulating key iron-regulatory genes may constitute a means of exploiting a metabolic adaptation necessary for tumor growth. Recent annual increases in PCa incidence have been reported, highlighting the urgent need for novel treatments. We examined the ability of LNCaP, PC3, VCaP, and VCaP-EnzR cells to form colonies in the presence of androgen receptor inhibitors (ARI) and a series of iron-gene modulating oligopeptides (FT-001-FT-008). The viability of colonies following treatment was determined with clonogenic assays, and the expression levels of
Identifiants
pubmed: 37894914
pii: ijms242015231
doi: 10.3390/ijms242015231
pmc: PMC10607736
pii:
doi:
Substances chimiques
Receptors, Androgen
0
Iron
E1UOL152H7
Androgens
0
Peptides
0
Receptors, Transferrin
0
FTH1 protein, human
EC 1.-
Ferritins
9007-73-2
Oxidoreductases
EC 1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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