Versatile lactate signaling via HCAR1: a multifaceted GPCR involved in many biological processes.
GPCR
HCAR1
lactate
location bias
location-biased signaling
signal transduction
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 12 2023
01 12 2023
Historique:
medline:
5
12
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
ppublish
Résumé
G-coupled protein receptors (GPCRs) are the ultimate refuge of pharmacology and medicine as more than 40% of all marketed drugs are directly targeting these receptors. Through cell surface expression, they are at the forefront of cellular communication with the outside world. Metabolites among the conveyors of this communication are becoming more prominent with the recognition of them as ligands for GPCRs. HCAR1 is a GPCR conveyor of lactate. It is a class A GPCR coupled to G
Identifiants
pubmed: 37899751
doi: 10.1152/ajpcell.00346.2023
doi:
Substances chimiques
Lactic Acid
33X04XA5AT
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
C1502-C1515Subventions
Organisme : Gouvernement du Canada | Canadian Institutes of Health Research (IRSC)