CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
07
07
2023
accepted:
12
08
2023
revised:
11
08
2023
medline:
4
12
2023
pubmed:
1
11
2023
entrez:
1
11
2023
Statut:
ppublish
Résumé
CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells. Traditionally, cytotoxic T cells, characterized by their ability to produce effector cytokines and release cytotoxic granules to directly kill target cells, have been recognized as the constituents of the predominant effector T-cell subset. However, emerging evidence suggests distinct subsets of effector CD8 T cells that each exhibit unique effector functions and therapeutic potential. This review highlights recent advancements in our understanding of CD8 T-cell subsets and the contributions of these cells to various disease pathologies. Understanding the diverse roles and functions of effector CD8 T-cell subsets is crucial to discern the complex dynamics of immune responses in different disease settings. Furthermore, the development of immunotherapeutic approaches that specifically target and regulate the function of distinct CD8 T-cell subsets holds great promise for precision medicine.
Identifiants
pubmed: 37907738
doi: 10.1038/s12276-023-01105-x
pii: 10.1038/s12276-023-01105-x
pmc: PMC10689838
doi:
Substances chimiques
Antigens
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2287-2299Subventions
Organisme : National Research Foundation of Korea (NRF)
ID : 2020R1A3B207889011
Organisme : National Research Foundation of Korea (NRF)
ID : 2022R1A6A1A03046247
Organisme : National Research Foundation of Korea (NRF)
ID : 2022R1C1C201061212
Informations de copyright
© 2023. The Author(s).
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