TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation.
ATF/CREB
CP: Molecular biology
TOR pathway
fission yeast
heterochromatin
ribosome
stress response
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
received:
08
05
2023
revised:
29
08
2023
accepted:
05
10
2023
medline:
4
12
2023
pubmed:
2
11
2023
entrez:
1
11
2023
Statut:
ppublish
Résumé
In response to environmental cues, such as nutrient starvation, living organisms modulate gene expression through mechanisms involving histone modifications. Specifically, nutrient depletion inactivates the TOR (target of rapamycin) pathway, leading to reduced expression of ribosomal genes. While these regulatory mechanisms are well elucidated in budding yeast Saccharomyces cerevisiae, their conservation across diverse organisms remains unclear. In this study, we demonstrate that fission yeast Schizosaccharomyces pombe cells repress ribosomal gene transcription through a different mechanism. TORC1, which accumulates in the rDNA region, dissociates upon starvation, resulting in enhanced methylation of H3K9 and heterochromatin formation, facilitated by dissociation of the stress-responsive transcription factor Atf1 and accumulation of the histone chaperone FACT. We propose that this mechanism might be adapted in mammals that possess Suv39H1 and HP1, which are absent in budding yeast.
Identifiants
pubmed: 37913773
pii: S2211-1247(23)01332-3
doi: 10.1016/j.celrep.2023.113320
pii:
doi:
Substances chimiques
Schizosaccharomyces pombe Proteins
0
Heterochromatin
0
DNA, Ribosomal
0
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113320Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.