Engineering semi-permeable giant liposomes.

Fatty Acids, Monounsaturated Unilamellar Liposomes / metabolism Membrane Proteins Permeability

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
21 Nov 2023
Historique:
medline: 27 11 2023
pubmed: 6 11 2023
entrez: 6 11 2023
Statut: epublish

Résumé

Giant unilamellar vesicles (GUVs) with a semi-permeable nature are prerequisites for constructing synthetic cells. Here we engineer semi-permeable GUVs by the inclusion of DOTAP lipid in vesicles. Diffusion of molecules of different charge and size across GUVs are reported. Control over size-selective permeability is demonstrated by modulating the DOTAP lipid composition in different lipid systems without reconstituting membrane proteins. Such semi-permeable GUVs have immense applications for constructing synthetic cells.

Identifiants

DOI: 10.1039/d3cc04039a PMID: 37930322
pubmed: 37930322
doi: 10.1039/d3cc04039a
doi:

Substances chimiques

1,2-dioleoyloxy-3-(trimethylammonium)propane MR86K0XRQP
Fatty Acids, Monounsaturated 0
Unilamellar Liposomes 0
Membrane Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13863-13866

Auteurs

Sreelakshmi Radhakrishnan (S)

Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Trivandrum 695019, Kerala, India. harshabajaj@niist.res.in.

Karthika S Nair (KS)

Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Trivandrum 695019, Kerala, India. harshabajaj@niist.res.in.
Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, Ghaziabad 201002, India.

Samir Nandi (S)

Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Trivandrum 695019, Kerala, India. harshabajaj@niist.res.in.

Harsha Bajaj (H)

Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Trivandrum 695019, Kerala, India. harshabajaj@niist.res.in.
Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, Ghaziabad 201002, India.
ORCID: 0000-0001-5422-5182

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Engineering semi-permeable giant liposomes.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Liposomes unilamellaires › Engineering semi-permeable giant liposomes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Engineering semi-permeable giant liposomes.
questionsmedicales.fr › Phénomènes chimiques › Perméabilité › Engineering semi-permeable giant liposomes.