In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121.

Peroxides Peracetic Acid Ligands Cytochrome P-450 Enzyme System / metabolism Iron Heme / chemistry Tyrosine Carbon

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
22 Nov 2023
Historique:
medline: 27 11 2023
pubmed: 8 11 2023
entrez: 8 11 2023
Statut: ppublish

Résumé

The P450 enzyme CYP121 from

Identifiants

DOI: 10.1021/jacs.3c04991 PMID: 37939223
pubmed: 37939223
doi: 10.1021/jacs.3c04991
doi:

Substances chimiques

cytochrome P-450 CYP121 0
Peroxides 0
Peracetic Acid I6KPI2E1HD
Ligands 0
Cytochrome P-450 Enzyme System 9035-51-2
Iron E1UOL152H7
Heme 42VZT0U6YR
Tyrosine 42HK56048U
Carbon 7440-44-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

25120-25133

Auteurs

Romie C Nguyen (RC)

Department of Chemistry, University of Texas, San Antonio, Texas 78249, United States.

Ian Davis (I)

Department of Chemistry, University of Texas, San Antonio, Texas 78249, United States.
ORCID: 0000-0002-1566-4972

Medhanjali Dasgupta (M)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Yifan Wang (Y)

Department of Chemistry, University of Texas, San Antonio, Texas 78249, United States.

Philipp S Simon (PS)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0002-2859-4475

Agata Butryn (A)

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA, United Kingdom.
ORCID: 0000-0002-5227-4770

Hiroki Makita (H)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Isabel Bogacz (I)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0003-1493-3867

Kednerlin Dornevil (K)

Department of Chemistry, University of Texas, San Antonio, Texas 78249, United States.

Pierre Aller (P)

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA, United Kingdom.
ORCID: 0000-0002-1793-7030

Asmit Bhowmick (A)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0002-6154-6635

Ruchira Chatterjee (R)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

In-Sik Kim (IS)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Tiankun Zhou (T)

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA, United Kingdom.

Derek Mendez (D)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Daniel W Paley (DW)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Franklin Fuller (F)

LCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.

Roberto Alonso Mori (R)

LCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
ORCID: 0000-0002-5357-0934

Alexander Batyuk (A)

LCLS, SLAC National Accelerator Laboratory, Menlo Park, California 94025, United States.
ORCID: 0000-0002-9393-2880

Nicholas K Sauter (NK)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0003-2786-6552

Aaron S Brewster (AS)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0002-0908-7822

Allen M Orville (AM)

Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, United Kingdom.
Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire OX11 0FA, United Kingdom.
ORCID: 0000-0002-7803-1777

Vittal K Yachandra (VK)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0002-3983-7858

Junko Yano (J)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
ORCID: 0000-0001-6308-9071

Jan F Kern (JF)

Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Aimin Liu (A)

Department of Chemistry, University of Texas, San Antonio, Texas 78249, United States.
ORCID: 0000-0002-4182-8176

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acide peracétique › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Tyrosine › In Situ Structural Observation of a Substrate-...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Carbone › In Situ Structural Observation of a Substrate-...