Side-Selective Solid-Phase Metallaphotoredox

Tryptophan / chemistry Peptides / chemistry Amino Acids / chemistry Oxidation-Reduction Solid-Phase Synthesis Techniques

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
06 Dec 2023
Historique:
medline: 7 12 2023
pubmed: 17 11 2023
entrez: 17 11 2023
Statut: ppublish

Résumé

Postsynthetic diversification of peptides through selective modification of endogenous amino acid side chains has enabled significant advances in peptide drug discovery while expanding the biological and medical chemistry space. However, current tools have been focused on the modification of reactive polar and ionizable side chains, whereas the decoration of aromatic systems (e.g., the

Identifiants

DOI: 10.1021/jacs.3c10792 PMID: 37976043
pubmed: 37976043
doi: 10.1021/jacs.3c10792
doi:

Substances chimiques

Tryptophan 8DUH1N11BX
Peptides 0
Amino Acids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26452-26462

Auteurs

José A C Delgado (JAC)

Laboratory for Sustainable Organic Synthesis and Catalysis, Department of Chemistry, Federal University of São Carlos─UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo 13565-905, Brazil.
Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg, Germany.
ORCID: 0000-0002-5994-7384

Ya-Ming Tian (YM)

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg, Germany.

Michela Marcon (M)

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg, Germany.
ORCID: 0000-0002-1201-1677

Burkhard König (B)

Institute of Organic Chemistry, University of Regensburg, 93040 Regensburg, Germany.
ORCID: 0000-0002-6131-4850

Márcio W Paixão (MW)

Laboratory for Sustainable Organic Synthesis and Catalysis, Department of Chemistry, Federal University of São Carlos─UFSCar, Rodovia Washington Luís, km 235, SP-310, São Carlos, São Paulo 13565-905, Brazil.
ORCID: 0000-0002-0421-2831

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Side-Selective Solid-Phase Metallaphotoredox
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Side-Selective Solid-Phase Metallaphotoredox
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Side-Selective Solid-Phase Metallaphotoredox
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Side-Selective Solid-Phase Metallaphotoredox
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Techniques de synthèse en phase solide › Side-Selective Solid-Phase Metallaphotoredox