Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB.
cell biology
cochlea
hair cell
inner ear
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 Nov 2023
20 Nov 2023
Historique:
received:
13
06
2023
accepted:
17
11
2023
medline:
11
12
2023
pubmed:
20
11
2023
entrez:
20
11
2023
Statut:
epublish
Résumé
The MRTF-SRF pathway has been extensively studied for its crucial role in driving the expression of a large number of genes involved in actin cytoskeleton of various cell types. However, the specific contribution of MRTF-SRF in hair cells remains unknown. In this study, we showed that hair cell-specific deletion of
Identifiants
pubmed: 37982489
doi: 10.7554/eLife.90155
pii: 90155
pmc: PMC10703445
doi:
pii:
Substances chimiques
Actins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82000975
Organisme : Fundamental Research Program Funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine
ID : JYZZ057
Organisme : Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases
ID : 14DZ2260300
Organisme : Shanghai Municipal Science and Technology Major Project
ID : 21JC1404000
Organisme : National Natural Science Foundation of China
ID : 81970872
Organisme : School of Medicine, Shanghai Jiao Tong University
ID : JYZZ057
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 21JC1404000
Informations de copyright
© 2023, Zhou et al.
Déclaration de conflit d'intérêts
LZ, CJ, WW, LS, JS, TD, HW No competing interests declared
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