RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in
DNA repair
RNA–DNA hybrid
antigenic variation
recombination
trypanosome
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
28 Nov 2023
28 Nov 2023
Historique:
medline:
27
11
2023
pubmed:
21
11
2023
entrez:
21
11
2023
Statut:
ppublish
Résumé
RNA-DNA hybrids are epigenetic features of all genomes that intersect with many processes, including transcription, telomere homeostasis, and centromere function. Increasing evidence suggests that RNA-DNA hybrids can provide two conflicting roles in the maintenance and transmission of genomes: They can be the triggers of DNA damage, leading to genome change, or can aid the DNA repair processes needed to respond to DNA lesions. Evasion of host immunity by African trypanosomes, such as
Identifiants
pubmed: 37988471
doi: 10.1073/pnas.2309306120
pmc: PMC10691351
doi:
Substances chimiques
DNA
9007-49-2
RNA
63231-63-0
Variant Surface Glycoproteins, Trypanosoma
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2309306120Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.
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