Casuattimines A-N, fourteen new Lycopodium alkaloids from Lycopodiastrum casuarinoides with Ca
Ca(v)3.1 blocker
Lycopodiastrum casuarinoides
Lycopodium alkaloid
T-type voltage-gated calcium channel
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
04
09
2023
revised:
28
10
2023
accepted:
07
11
2023
medline:
28
11
2023
pubmed:
23
11
2023
entrez:
22
11
2023
Statut:
ppublish
Résumé
Two new dimeric Lycopodium alkaloids, casuattimines A and B (1 and 2), along with twelve previously undescribed Lycopodium alkaloids, casuattimines C-N (3-14), and eight known Lycopodium alkaloids, were isolated from Lycopodiastrum casuarinoides. Casuattimines A and B (1 and 2) are the first two ether-linked Lycopodium alkaloid dimers. Casuattimines C and D (3 and 4) are unique Lycopodium alkaloids characterized by a long fatty acid chain. Structural elucidation was achieved through HRESIMS, NMR, and electronic circular dichroism (ECD) calculations. In addition, the absolute configurations of compounds 7, 13, and 14 were determined by single crystal X-ray diffraction. Compounds 1, 2, and 4 demonstrated notable Ca
Identifiants
pubmed: 37992623
pii: S0045-2068(23)00623-5
doi: 10.1016/j.bioorg.2023.106962
pii:
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Alkaloids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106962Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.