Small RNA Sequencing Reveals a Distinct MicroRNA Signature between Glucocorticoid Responder and Glucocorticoid Non-Responder Primary Human Trabecular Meshwork Cells after Dexamethasone Treatment.
glaucoma
glucocorticoids
intra-ocular pressure
miRNA
microRNAs
ocular hypertension
pathway analysis
small RNA-Seq
trabecular meshwork
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
27 Oct 2023
27 Oct 2023
Historique:
received:
14
09
2023
revised:
22
10
2023
accepted:
23
10
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Glucocorticoids (GCs) are known to regulate several physiological processes and are the mainstay in the management of inflammatory eye diseases. The long-term use of GC causes raised intraocular pressure (IOP) or ocular hypertension (OHT) in about 30-50% of the susceptible individuals depending on the route of administration, and can lead to steroid-induced secondary glaucoma. The present study aims to understand the role of microRNAs (miRNAs) in differential glucocorticoid (GC) responsiveness in human trabecular meshwork (HTM) cells using small RNA sequencing. The human organ-cultured anterior segment (HOCAS) model was used to identify whether donor eyes were from GC-responders (GC-R;
Identifiants
pubmed: 38002955
pii: genes14112012
doi: 10.3390/genes14112012
pmc: PMC10671261
pii:
doi:
Substances chimiques
Glucocorticoids
0
MicroRNAs
0
Dexamethasone
7S5I7G3JQL
Steroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
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