Homologous Recombination and Repair Functions Required for Mutagenicity during Yeast Meiosis.
DNA double-strand breaks (DSBs)
DNA repair
homologous recombination
meiosis
mutations
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
28 Oct 2023
28 Oct 2023
Historique:
received:
29
09
2023
revised:
22
10
2023
accepted:
23
10
2023
medline:
27
11
2023
pubmed:
25
11
2023
entrez:
25
11
2023
Statut:
epublish
Résumé
Several meiotic events reshape the genome prior to its transfer (via gametes) to the next generation. The occurrence of new meiotic mutations is tightly linked to homologous recombination (HR) and firmly depends on Spo11-induced DNA breaks. To gain insight into the molecular mechanisms governing mutagenicity during meiosis, we examined the timing of mutation and recombination events in cells deficient in various DNA HR-repair genes, which represent distinct functions along the meiotic recombination process. Despite sequence similarities and overlapping activities of the two DNA translocases, Rad54 and Tid1, we observed essential differences in their roles in meiotic mutation occurrence: in the absence of Rad54, meiotic mutagenicity was elevated 8-fold compared to the wild type (WT), while in the
Identifiants
pubmed: 38002960
pii: genes14112017
doi: 10.3390/genes14112017
pmc: PMC10671739
pii:
doi:
Substances chimiques
Mutagens
0
Saccharomyces cerevisiae Proteins
0
DNA
9007-49-2
DNA, Single-Stranded
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : Grant # 501/16
Organisme : Israel Science Foundation
ID : Grant # 397/20
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