Enhancing Anticancer Efficacy of Formononetin Microspheres via Microfluidic Fabrication.

Polylactic Acid-Polyglycolic Acid Copolymer Lactic Acid Polyglycolic Acid Microspheres Microfluidics Particle Size
anti-tumor formononetin lung cancer microfluidic microspheres

Journal

AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111

Informations de publication

Date de publication:
28 Nov 2023
Historique:
received: 19 07 2023
accepted: 30 10 2023
medline: 30 11 2023
pubmed: 29 11 2023
entrez: 28 11 2023
Statut: epublish

Résumé

Formononetin is a flavonoid compound with anti-tumor and anti-inflammatory properties. However, its low solubility limits its clinical use. We employed microfluidic technology to prepare formononetin-loaded PLGA-PEGDA microspheres (Degradable polymer PLGA, Crosslinking agent PEGDA), which can encapsulate and release drugs in a controlled manner. We optimized and characterized the microspheres, and evaluated their antitumor effects. The microspheres had uniform size, high drug loading efficiency, high encapsulation efficiency, and stable release for 35 days. They also inhibited the proliferation, migration, and apoptosis. The antitumor mechanism involved the induction of reactive oxygen species and modulation of Bcl-2 family proteins. These findings suggested that formononetin-loaded PLGA-PEGDA microspheres, created using microfluidic technology, could be a novel drug delivery system that can overcome the limitations of formononetin and enhance its antitumor activity.

Identifiants

DOI: 10.1208/s12249-023-02691-9 PMID: 38017231
pubmed: 38017231
doi: 10.1208/s12249-023-02691-9
pii: 10.1208/s12249-023-02691-9
doi:

Substances chimiques

Polylactic Acid-Polyglycolic Acid Copolymer 1SIA8062RS
Lactic Acid 33X04XA5AT
Polyglycolic Acid 26009-03-0
formononetin 295DQC67BJ
poly(ethylene glycol)diacrylate 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

241

Informations de copyright

© 2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.

Références

Zhang S, Sun J. Nano-drug delivery system for the treatment of acute myelogenous leukemia. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022;51(2):233–40. https://doi.org/10.3724/zdxbyxb-2022-0084 .
doi: 10.3724/zdxbyxb-2022-0084 pubmed: 35713321 pmcid: 9353639
Qamar Z, Qizilbash FF, Iqubal MK, Ali A, Narang JK, Ali J, et al. Nano-based drug delivery system: recent strategies for the treatment of ocular disease and future perspective. Recent Pat Drug Deliv Formul. 2019;13(4):246–54. https://doi.org/10.2174/1872211314666191224115211 .
doi: 10.2174/1872211314666191224115211 pubmed: 31884933 pmcid: 7499345
Li B, Shao H, Gao L, Li H, Sheng H, Zhu L. Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review. Drug Deliv. 2022;29(1):2130–61. https://doi.org/10.1080/10717544.2022.2094498 .
doi: 10.1080/10717544.2022.2094498 pubmed: 35815678 pmcid: 9275501
Xie M, Xu Y, Shen H, Shen S, Ge Y, Xie J. Negative-charge-functionalized mesoporous silica nanoparticles as drug vehicles targeting hepatocellular carcinoma. Int J Pharm. 2014;474(1-2):223–31. https://doi.org/10.1016/j.ijpharm.2014.08.027 .
doi: 10.1016/j.ijpharm.2014.08.027 pubmed: 25149125
Rui M, Xing Y, Li R, Ge Y, Feng C, Xu X. Targeted biomimetic nanoparticles for synergistic combination chemotherapy of paclitaxel and doxorubicin. Molecular Pharmaceutics. 2017;14(1):107–23. https://doi.org/10.1021/acs.molpharmaceut.6b00732 .
doi: 10.1021/acs.molpharmaceut.6b00732 pubmed: 27982602
Hussein HA, Nazir MS, Azra N, Qamar Z, Seeni A, Tengku Din T, et al. Novel drug and gene delivery system and imaging agent based on marine diatom biosilica nanoparticles. Mar Drugs. 2022;20(8) https://doi.org/10.3390/md20080480 .
Machado Dutra J, Espitia PJP, Andrade BR. Formononetin: biological effects and uses - a review. Food Chem. 2021;359:129975. https://doi.org/10.1016/j.foodchem.2021.129975 .
doi: 10.1016/j.foodchem.2021.129975 pubmed: 33962193
Mendonça MAA, Ribeiro ARS, Lima AK, Bezerra GB, Pinheiro MS, Albuquerque-Júnior RLC, et al. Red propolis and its dyslipidemic regulator formononetin: evaluation of antioxidant activity and gastroprotective effects in rat model of gastric ulcer. Nutrients. 2020;12(10) https://doi.org/10.3390/nu12102951 .
Zhang B, Hao Z, Zhou W, Zhang S, Sun M, Li H, et al. Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation. Bioengineered. 2021;12(1):4887–98. https://doi.org/10.1080/21655979.2021.1959493 .
doi: 10.1080/21655979.2021.1959493 pubmed: 34369277 pmcid: 8806800
Tian J, Wang XQ, Tian Z. Focusing on formononetin: recent perspectives for its neuroprotective potentials. Front Pharmacol. 2022;13:905898. https://doi.org/10.3389/fphar.2022.905898 .
doi: 10.3389/fphar.2022.905898 pubmed: 35712702 pmcid: 9196267
Tay KC, Tan LT, Chan CK, Hong SL, Chan KG, Yap WH, et al. Formononetin: a review of its anticancer potentials and mechanisms. Front Pharmacol. 2019;10:820. https://doi.org/10.3389/fphar.2019.00820 .
doi: 10.3389/fphar.2019.00820 pubmed: 31402861 pmcid: 6676344
Yu L, Zhang Y, Chen Q, He Y, Zhou H, Wan H, et al. Formononetin protects against inflammation associated with cerebral ischemia-reperfusion injury in rats by targeting the JAK2/STAT3 signaling pathway. Biomed Pharmacother. 2022;149:112836. https://doi.org/10.1016/j.biopha.2022.112836 .
doi: 10.1016/j.biopha.2022.112836 pubmed: 35339827
Ma X, Wang J. Formononetin: a pathway to protect neurons. Front Integr Neurosci. 2022;16:908378. https://doi.org/10.3389/fnint.2022.908378 .
doi: 10.3389/fnint.2022.908378 pubmed: 35910340 pmcid: 9326316
Wang QY, Meng QH, Zhang ZT, Tian ZJ, Liu H. Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin. Yao Xue Xue Bao. 2009;44(4):386–9.
pubmed: 19545056
Ong SKL, Shanmugam MK, Fan L, Fraser SE, Arfuso F, Ahn KS, et al. Focus on formononetin: anticancer potential and molecular targets. Cancers (Basel). 2019;11(5) https://doi.org/10.3390/cancers11050611 .
Zhang J, Liu L, Wang J, Ren B, Zhang L, Li W. Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells. J Ethnopharmacol. 2018;221:91–9. https://doi.org/10.1016/j.jep.2018.04.014 .
doi: 10.1016/j.jep.2018.04.014 pubmed: 29660466
Almatroodi SA, Almatroudi A, Khan AA, Rahmani AH. Potential therapeutic targets of formononetin, a type of methoxylated isoflavone, and its role in cancer therapy through the modulation of signal transduction pathways. Int J Mol Sci. 2023;24(11) https://doi.org/10.3390/ijms24119719 .
Yang Y, Zhao Y, Ai X, Cheng B, Lu S. Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis. Int J Clin Exp Pathol. 2014;7(12):8453–61.
pubmed: 25674209 pmcid: 4313991
Zhang L, Gong Y, Wang S, Gao F. Anti-colorectal cancer mechanisms of formononetin identified by network pharmacological approach. Med Sci Monit. 2019;25:7709–14. https://doi.org/10.12659/msm.919935 .
doi: 10.12659/msm.919935 pubmed: 31608899 pmcid: 6812471
Li S, Zhu L, He Y, Sun T. Formononetin enhances the chemosensitivity of triple negative breast cancer via BTB domain and CNC homolog 1-mediated mitophagy pathways. Acta Biochim Pol. 2023;70(3):533–9. https://doi.org/10.18388/abp.2020_6466 .
doi: 10.18388/abp.2020_6466 pubmed: 37672716
Wang Y, Deng Z, Wang X, Shi Y, Lu Y, Fang S, et al. Formononetin/methyl-β-cyclodextrin inclusion complex incorporated into electrospun polyvinyl-alcohol nanofibers: enhanced water solubility and oral fast-dissolving property. Int J Pharm. 2021;603:120696. https://doi.org/10.1016/j.ijpharm.2021.120696 .
doi: 10.1016/j.ijpharm.2021.120696 pubmed: 33984451
Kim JH, Kang DW, Cho SJ, Cho HY. Parent-metabolite pharmacokinetic modeling of formononetin and its active metabolites in rats after oral administration of formononetin formulations. Pharmaceutics. 2022;15(1) https://doi.org/10.3390/pharmaceutics15010045 .
Zhang HY, Firempong CK, Wang YW, Xu WQ, Wang MM, Cao X, et al. Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability. Acta Pharmacologica Sinica. 2016;37(6):834–44. https://doi.org/10.1038/aps.2016.37 .
doi: 10.1038/aps.2016.37 pubmed: 27133301 pmcid: 4954769
Cao X, Deng W, Wei Y, Su W, Yang Y, Wei Y, et al. Encapsulation of plasmid DNA in calcium phosphate nanoparticles: stem cell uptake and gene transfer efficiency. Int J Nanomedicine. 2011;6:3335–49. https://doi.org/10.2147/ijn.S27370 .
doi: 10.2147/ijn.S27370 pubmed: 22229000 pmcid: 3252680
Bian J, Cai F, Chen H, Tang Z, Xi K, Tang J, et al. Modulation of local overactive inflammation via injectable hydrogel microspheres. Nano Lett. 2021;21(6):2690–8. https://doi.org/10.1021/acs.nanolett.0c04713 .
doi: 10.1021/acs.nanolett.0c04713 pubmed: 33543616
Yang J, Han Y, Lin J, Zhu Y, Wang F, Deng L, et al. Ball-bearing-inspired polyampholyte-modified microspheres as bio-lubricants attenuate osteoarthritis. Small. 2020;16(44):e2004519. https://doi.org/10.1002/smll.202004519 .
doi: 10.1002/smll.202004519 pubmed: 32940012
Zhang Q, Yang T, Zhang R, Liang X, Wang G, Tian Y, et al. Platelet lysate functionalized gelatin methacrylate microspheres for improving angiogenesis in endodontic regeneration. Acta Biomater. 2021;136:441–55. https://doi.org/10.1016/j.actbio.2021.09.024 .
doi: 10.1016/j.actbio.2021.09.024 pubmed: 34551330
Wong CY, Al-Salami H, Dass CR. Microparticles, microcapsules and microspheres: a review of recent developments and prospects for oral delivery of insulin. Int J Pharm. 2018;537(1-2):223–44. https://doi.org/10.1016/j.ijpharm.2017.12.036 .
doi: 10.1016/j.ijpharm.2017.12.036 pubmed: 29288095
Li W, Chen J, Zhao S, Huang T, Ying H, Trujillo C, et al. High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury. Nat Commun. 2022;13(1):1262. https://doi.org/10.1038/s41467-022-28787-7 .
doi: 10.1038/s41467-022-28787-7 pubmed: 35273148 pmcid: 8913677
Zhang Y, Shen L, Wang T, Li H, Huang R, Zhang Z, et al. Taste masking of water-soluble drug by solid lipid microspheres: a child-friendly system established by reversed lipid-based nanoparticle technique. J Pharm Pharmacol. 2020;72(6):776–86. https://doi.org/10.1111/jphp.13245 .
doi: 10.1111/jphp.13245 pubmed: 32153037
Gouerou H, Dain MP, Parrondo I, Poisson D, Bernades P. Alipase versus nonenteric-coated enzymes in pancreatic insufficiency. A French multicenter crossover comparative study. Int J Pancreatol. 1989;5(Suppl):45–50.
pubmed: 2702250
Su Y, Liu J, Tan S, Liu W, Wang R, Chen C. PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo. Drug Deliv. 2022;29(1):1437–46. https://doi.org/10.1080/10717544.2022.2072413 .
doi: 10.1080/10717544.2022.2072413 pubmed: 35532150 pmcid: 9090356
Ghosh Dastidar D, Saha S, Chowdhury M. Porous microspheres: synthesis, characterisation and applications in pharmaceutical & medical fields. Int J Pharm. 2018;548(1):34–48. https://doi.org/10.1016/j.ijpharm.2018.06.015 .
doi: 10.1016/j.ijpharm.2018.06.015 pubmed: 29940297
Larsen LI, López GP, Selwyn R, Carroll NJ. Microfluidic fabrication of silica microspheres infused with positron emission tomography imaging agents. ACS Appl Bio Mater. 2023;6(2):712–21. https://doi.org/10.1021/acsabm.2c00940 .
doi: 10.1021/acsabm.2c00940 pubmed: 36633291
Cao X, Liu Q, Adu-Frimpong M, Shi W, Liu K, Deng T, et al. Microfluidic generation of near-infrared photothermal vitexin/ICG liposome with amplified photodynamic therapy. AAPS PharmSciTech. 2023;24(4):82. https://doi.org/10.1208/s12249-023-02539-2 .
doi: 10.1208/s12249-023-02539-2 pubmed: 36949351
Zhao Q, Cui H, Wang Y, Du X. Microfluidic platforms toward rational material fabrication for biomedical applications. Small. 2020;16(9):e1903798. https://doi.org/10.1002/smll.201903798 .
doi: 10.1002/smll.201903798 pubmed: 31650698
Lin Z, Rao Z, Chen J, Chu H, Zhou J, Yang L, et al. Bioactive decellularized extracellular matrix hydrogel microspheres fabricated using a temperature-controlling microfluidic system. ACS Biomater Sci Eng. 2022;8(4):1644–55. https://doi.org/10.1021/acsbiomaterials.1c01474 .
doi: 10.1021/acsbiomaterials.1c01474 pubmed: 35357124
Amini H, Lee W, Di Carlo D. Inertial microfluidic physics. Lab Chip. 2014;14(15):2739–61. https://doi.org/10.1039/c4lc00128a .
doi: 10.1039/c4lc00128a pubmed: 24914632
Yao Y, Lin JJ, Chee XYJ, Liu MH, Khan SA, Kim JE. Encapsulation of lutein via microfluidic technology: evaluation of stability and in vitro bioaccessibility. Foods. 2021;10(11) https://doi.org/10.3390/foods10112646 .
Seeto WJ, Tian Y, Pradhan S, Kerscher P, Lipke EA. Rapid production of cell-laden microspheres using a flexible microfluidic encapsulation platform. Small. 2019;15(47):e1902058. https://doi.org/10.1002/smll.201902058 .
doi: 10.1002/smll.201902058 pubmed: 31468632
Bolze H, Erfle P, Riewe J, Bunjes H, Dietzel A, Burg TP. A microfluidic split-flow technology for product characterization in continuous low-volume nanoparticle synthesis. Micromachines (Basel). 2019;10(3) https://doi.org/10.3390/mi10030179 .
Wu S, Wang Z, Wang Y, Guo M, Zhou M, Wang L, et al. Peptide-grafted microspheres for mesenchymal stem cell sorting and expansion by selective adhesion. Front Bioeng Biotechnol. 2022;10:873125. https://doi.org/10.3389/fbioe.2022.873125 .
doi: 10.3389/fbioe.2022.873125 pubmed: 35497366 pmcid: 9039221
Zhou W, Dou M, Timilsina SS, Xu F, Li X. Recent innovations in cost-effective polymer and paper hybrid microfluidic devices. Lab Chip. 2021;21(14):2658–83. https://doi.org/10.1039/d1lc00414j .
doi: 10.1039/d1lc00414j pubmed: 34180494 pmcid: 8360634
Siavashy S, Soltani M, Ghorbani-Bidkorbeh F, Fallah N, Farnam G, Mortazavi SA, et al. Microfluidic platform for synthesis and optimization of chitosan-coated magnetic nanoparticles in cisplatin delivery. Carbohydr Polym. 2021;265:118027. https://doi.org/10.1016/j.carbpol.2021.118027 .
doi: 10.1016/j.carbpol.2021.118027 pubmed: 33966822
Hernández-Giottonini KY, Rodríguez-Córdova RJ, Gutiérrez-Valenzuela CA, Peñuñuri-Miranda O, Zavala-Rivera P, Guerrero-Germán P, et al. PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters. RSC Adv. 2020;10(8):4218–31. https://doi.org/10.1039/c9ra10857b .
doi: 10.1039/c9ra10857b pubmed: 35495261 pmcid: 9049000
Wang S, Liang WF, Dong ZL, Lee VGB, Li WJ. Fabrication of micrometer- and nanometer-scale polymer structures by visible light induced dielectrophoresis (DEP) force. Micromachines. 2011;2(4):431–42. https://doi.org/10.3390/mi2040431 .
doi: 10.3390/mi2040431
Blasi P. Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview. Journal of Pharmaceutical Investigation. 2019;49(4):337–46. https://doi.org/10.1007/s40005-019-00453-z .
doi: 10.1007/s40005-019-00453-z
He C, Zeng W, Su Y, Sun R, Xiao Y, Zhang B, et al. Microfluidic-based fabrication and characterization of drug-loaded PLGA magnetic microspheres with tunable shell thickness. Drug Deliv. 2021;28(1):692–9. https://doi.org/10.1080/10717544.2021.1905739 .
doi: 10.1080/10717544.2021.1905739 pubmed: 33818236 pmcid: 8023598
Chen M, Aluunmani R, Bolognesi G, Vladisavljević GT. Facile microfluidic fabrication of biocompatible hydrogel microspheres in a novel microfluidic device. Molecules. 2022:27(13). https://doi.org/10.3390/molecules27134013 .
Wang X, Wang L, Qi F, Zhao J. The effect of a single injection of uniform-sized insulin-loaded PLGA microspheres on peri-implant bone formation. RSC Adv. 2018;8(70):40417–25. https://doi.org/10.1039/c8ra08505f .
doi: 10.1039/c8ra08505f pubmed: 35558211 pmcid: 9091419
Li X, Xia X, Zhang J, Adu-Frimpong M, Shen X, Yin W, et al. Preparation, physical characterization, pharmacokinetics and anti-hyperglycemic activity of esculetin-loaded mixed micelles. J Pharm Sci. 2023;112(1):148–57. https://doi.org/10.1016/j.xphs.2022.06.022 .
doi: 10.1016/j.xphs.2022.06.022 pubmed: 35780820
Zhu Z, Liu J, Yang Y, Adu-Frimpong M, Ji H, Toreniyazov E, et al. SMEDDS for improved oral bioavailability and anti-hyperuricemic activity of licochalcone A. J Microencapsul. 2021;38(7-8):459–71. https://doi.org/10.1080/02652048.2021.1963341 .
doi: 10.1080/02652048.2021.1963341 pubmed: 34338606
Jafarifar E, Hajialyani M, Akbari M, Rahimi M, Shokoohinia Y, Fattahi A. Preparation of a reproducible long-acting formulation of risperidone-loaded PLGA microspheres using microfluidic method. Pharm Dev Technol. 2017;22(6):836–43. https://doi.org/10.1080/10837450.2016.1221426 .
doi: 10.1080/10837450.2016.1221426 pubmed: 27494230
El-Didamony SE, Amer RI, El-Osaily GH. Formulation, characterization and cellular toxicity assessment of a novel bee-venom microsphere in prostate cancer treatment. Sci Rep. 2022;12(1):13213. https://doi.org/10.1038/s41598-022-17391-w .
doi: 10.1038/s41598-022-17391-w pubmed: 35918370 pmcid: 9346107
Cao X, Zhu Q, Wang QL, Adu-Frimpong M, Wei CM, Weng W, et al. Improvement of oral bioavailability and anti-tumor effect of zingerone self-microemulsion drug delivery system. J Pharm Sci. 2021;110(7):2718–27. https://doi.org/10.1016/j.xphs.2021.01.037 .
doi: 10.1016/j.xphs.2021.01.037 pubmed: 33610568
Yi C, Zhong H, Tong S, Cao X, Firempong CK, Liu H, et al. Enhanced oral bioavailability of a sterol-loaded microemulsion formulation of Flammulina velutipes, a potential antitumor drug. International Journal of Nanomedicine. 2012;7:5067–78. https://doi.org/10.2147/ijn.S34612 .
doi: 10.2147/ijn.S34612 pubmed: 23049254 pmcid: 3459840
Marulanda K, Brokaw D, Gambarian M, Pareta R, McQuilling JP, Opara EC, et al. Controlled delivery of Slit3 proteins from alginate microbeads inhibits in vitro angiogenesis. J Surg Res. 2021;264:90–8. https://doi.org/10.1016/j.jss.2021.01.025 .
doi: 10.1016/j.jss.2021.01.025 pubmed: 33794389
Pijuan J, Barceló C, Moreno DF, Maiques O, Sisó P, Marti RM, et al. In vitro cell migration, invasion, and adhesion assays: from cell imaging to data analysis. Front Cell Dev Biol. 2019;7:107. https://doi.org/10.3389/fcell.2019.00107 .
doi: 10.3389/fcell.2019.00107 pubmed: 31259172 pmcid: 6587234
Ayyanaar S, Kesavan MP, Balachandran C, Rasala S, Rameshkumar P, Aoki S, et al. Iron oxide nanoparticle core-shell magnetic microspheres: applications toward targeted drug delivery. Nanomedicine. 2020;24:102134. https://doi.org/10.1016/j.nano.2019.102134 .
doi: 10.1016/j.nano.2019.102134 pubmed: 31830615
Sun C, Li W, Liu Y, Deng W, Adu-Frimpong M, Zhang H, et al. In vitro/in vivo hepatoprotective properties of 1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside from Moringa oleifera seeds against carbon tetrachloride-induced hepatic injury. Food Chem Toxicol. 2019;131:110531. https://doi.org/10.1016/j.fct.2019.05.039 .
doi: 10.1016/j.fct.2019.05.039 pubmed: 31136780
Hu W, Xiao Z. Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo. Cell Physiol Biochem. 2015;37(3):933–9. https://doi.org/10.1159/000430220 .
doi: 10.1159/000430220 pubmed: 26381132
Aladaileh SH, Hussein OE, Abukhalil MH, Saghir SAM, Bin-Jumah M, Alfwuaires MA, et al. Formononetin upregulates Nrf2/HO-1 signaling and prevents oxidative stress, inflammation, and kidney injury in methotrexate-induced rats. Antioxidants (Basel). 2019;8(10) https://doi.org/10.3390/antiox8100430 .
Sun X, Lv W, Wang Y, Zhang X, Ouyang Z, Yin R, et al. Mrgprb2 gene plays a role in the anaphylactoid reactions induced by Houttuynia cordata injection. Journal of Ethnopharmacology. 2022:289. https://doi.org/10.1016/j.jep.2022.115053 .
Shi W, Cao X, Liu Q, Zhu Q, Liu K, Deng T, et al. Hybrid membrane-derived nanoparticles for isoliquiritin enhanced glioma therapy. Pharmaceuticals (Basel). 2022;15(9) https://doi.org/10.3390/ph15091059 .
Cao X, Deng T, Zhu Q, Wang J, Shi W, Liu Q, et al. Photothermal therapy mediated hybrid membrane derived nano-formulation for enhanced cancer therapy. AAPS PharmSciTech. 2023;24(6):146. https://doi.org/10.1208/s12249-023-02594-9 .
doi: 10.1208/s12249-023-02594-9 pubmed: 37380936
Ding D, Zhu Q. Recent advances of PLGA micro/nanoparticles for the delivery of biomacromolecular therapeutics. Mater Sci Eng C Mater Biol Appl. 2018;92:1041–60. https://doi.org/10.1016/j.msec.2017.12.036 .
doi: 10.1016/j.msec.2017.12.036 pubmed: 30184728
Mahar R, Chakraborty A, Nainwal N, Bahuguna R, Sajwan M, Jakhmola V. Application of PLGA as a biodegradable and biocompatible polymer for pulmonary delivery of drugs. AAPS PharmSciTech. 2023;24(1):39. https://doi.org/10.1208/s12249-023-02502-1 .
doi: 10.1208/s12249-023-02502-1 pubmed: 36653547
Hajavi J, Ebrahimian M, Sankian M, Khakzad MR, Hashemi M. Optimization of PLGA formulation containing protein or peptide-based antigen: recent advances. J Biomed Mater Res A. 2018;106(9):2540–51. https://doi.org/10.1002/jbm.a.36423 .
doi: 10.1002/jbm.a.36423 pubmed: 29633511
Abdul Rahim R, Jayusman PA, Muhammad N, Ahmad F, Mokhtar N, Naina Mohamed I, et al. Recent advances in nanoencapsulation systems using PLGA of bioactive phenolics for protection against chronic diseases. Int J Environ Res Public Health. 2019;16(24) https://doi.org/10.3390/ijerph16244962 .
Butreddy A, Gaddam RP, Kommineni N, Dudhipala N, Voshavar C. PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery. Int J Mol Sci. 2021;22(16) https://doi.org/10.3390/ijms22168884 .
Muddineti OS, Omri A. Current trends in PLGA based long-acting injectable products: the industry perspective. Expert Opin Drug Deliv. 2022;19(5):559–76. https://doi.org/10.1080/17425247.2022.2075845 .
doi: 10.1080/17425247.2022.2075845 pubmed: 35534912
McAvoy K, Jones D, Thakur RRS. Synthesis and characterisation of photocrosslinked poly(ethylene glycol) diacrylate implants for sustained ocular drug delivery. Pharm Res. 2018;35(2):36. https://doi.org/10.1007/s11095-017-2298-9 .
doi: 10.1007/s11095-017-2298-9 pubmed: 29368249 pmcid: 5784000
Sabel-Grau T, Tyushina A, Babalik C, Lensen MC. UV-VIS curable PEG hydrogels for biomedical applications with multifunctionality. Gels. 2022;8(3) https://doi.org/10.3390/gels8030164 .
Bhardwaj VK, Purohit R. A comparative study on inclusion complex formation between formononetin and β-cyclodextrin derivatives through multiscale classical and umbrella sampling simulations. Carbohydr Polym. 2023;310:120729. https://doi.org/10.1016/j.carbpol.2023.120729 .
doi: 10.1016/j.carbpol.2023.120729 pubmed: 36925262
Obaidat R, BaniAmer F, Assaf SM, Yassin A. Fabrication and evaluation of transdermal delivery of carbamazepine dissolving microneedles. AAPS PharmSciTech. 2021;22(8):253. https://doi.org/10.1208/s12249-021-02136-1 .
doi: 10.1208/s12249-021-02136-1 pubmed: 34668082
Liu J, Wang Q, Omari-Siaw E, Adu-Frimpong M, Liu J, Xu X, et al. Enhanced oral bioavailability of bisdemethoxycurcumin-loaded self-microemulsifying drug delivery system: formulation design, in vitro and in vivo evaluation. Int J Pharm. 2020;590:119887. https://doi.org/10.1016/j.ijpharm.2020.119887 .
doi: 10.1016/j.ijpharm.2020.119887 pubmed: 32950666
Wang Q, Wei Q, Yang Q, Cao X, Li Q, Shi F, et al. A novel formulation of [6]-gingerol: proliposomes with enhanced oral bioavailability and antitumor effect. Int J Pharm. 2018;535(1-2):308–15. https://doi.org/10.1016/j.ijpharm.2017.11.006 .
doi: 10.1016/j.ijpharm.2017.11.006 pubmed: 29126908
Löf D, Schillén K, Nilsson L. Flavonoids: precipitation kinetics and interaction with surfactant micelles. J Food Sci. 2011;76(3):N35–9. https://doi.org/10.1111/j.1750-3841.2011.02103.x .
doi: 10.1111/j.1750-3841.2011.02103.x pubmed: 21535850
Kim MS, Park JS, Chung YC, Jang S, Hyun CG, Kim SY. Anti-inflammatory effects of formononetin 7-O-phosphate, a novel biorenovation product, on LPS-stimulated RAW 264.7 macrophage cells. Molecules. 2019;24(21) https://doi.org/10.3390/molecules24213910 .
Karmakar J, Mukherjee K, Mandal C. Siglecs modulate activities of immune cells through positive and negative regulation of ROS generation. Front Immunol. 2021;12:758588. https://doi.org/10.3389/fimmu.2021.758588 .
doi: 10.3389/fimmu.2021.758588 pubmed: 34804046 pmcid: 8595208
He L, He T, Farrar S, Ji L, Liu T, Ma X. Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem. 2017;44(2):532–53. https://doi.org/10.1159/000485089 .
doi: 10.1159/000485089 pubmed: 29145191
Li T, Gao SJ. KSHV hijacks FoxO1 to promote cell proliferation and cellular transformation by antagonizing oxidative stress. J Med Virol. 2023;95(3):e28676. https://doi.org/10.1002/jmv.28676 .
doi: 10.1002/jmv.28676 pubmed: 36929740
Rahman MA, Ahmed KR, Haque F, Park MN, Kim B. Recent advances in cellular signaling interplay between redox metabolism and autophagy modulation in cancer: an overview of molecular mechanisms and therapeutic interventions. Antioxidants (Basel). 2023;12(2) https://doi.org/10.3390/antiox12020428 .
Zhan Y, Zhang Z, Liu Y, Fang Y, Xie Y, Zheng Y, et al. NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma. BMC Med. 2022;20(1):365. https://doi.org/10.1186/s12916-022-02554-3 .
doi: 10.1186/s12916-022-02554-3 pubmed: 36258210 pmcid: 9580158
Sun C, Li W, Ma P, Li Y, Zhu Y, Zhang H, et al. Development of TPGS/F127/F68 mixed polymeric micelles: enhanced oral bioavailability and hepatoprotection of syringic acid against carbon tetrachloride-induced hepatotoxicity. Food Chem Toxicol. 2020;137:111126. https://doi.org/10.1016/j.fct.2020.111126 .
doi: 10.1016/j.fct.2020.111126 pubmed: 31954714
Lai PK, Chan JY, Cheng L, Lau CP, Han SQ, Leung PC, et al. Isolation of anti-inflammatory fractions and compounds from the root of Astragalus membranaceus. Phytother Res. 2013;27(4):581–7. https://doi.org/10.1002/ptr.4759 .
doi: 10.1002/ptr.4759 pubmed: 22693074
Wang DS, Yan LY, Yang DZ, Lyu Y, Fang LH, Wang SB, et al. Formononetin ameliorates myocardial ischemia/reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway. Biochem Biophys Res Commun. 2020;525(3):759–66. https://doi.org/10.1016/j.bbrc.2020.02.147 .
doi: 10.1016/j.bbrc.2020.02.147 pubmed: 32145915
Fan TJ, Han LH, Cong RS, Liang J. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai). 2005;37(11):719–27. https://doi.org/10.1111/j.1745-7270.2005.00108.x .
doi: 10.1111/j.1745-7270.2005.00108.x pubmed: 16270150
Xiong Y, Tang YD, Zheng C. The crosstalk between the caspase family and the cGAS–STING signaling pathway. J Mol Cell Biol. 2021;13(10):739–47. https://doi.org/10.1093/jmcb/mjab071 .
doi: 10.1093/jmcb/mjab071 pubmed: 34718659 pmcid: 8718194
Van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease. Immunity. 2019;50(6):1352–64. https://doi.org/10.1016/j.immuni.2019.05.020 .
doi: 10.1016/j.immuni.2019.05.020 pubmed: 31216460 pmcid: 6611727
Zhang X, Bi L, Ye Y, Chen J. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 2014;66(4):656–61. https://doi.org/10.1080/01635581.2014.894098 .
doi: 10.1080/01635581.2014.894098 pubmed: 24666255
Zha Q, Zhang L, Guo Y, Bao R, Shi F, Shi Y. Preparation and study of folate modified albumin targeting microspheres. J Oncol. 2022;2022:3968403. https://doi.org/10.1155/2022/3968403 .
doi: 10.1155/2022/3968403 pubmed: 35126516 pmcid: 8816550
Wang L, Wang YS, Chen RY, Feng CL, Wang H, Zhu XW, et al. PLGA microspheres as a delivery vehicle for sustained release of tetracycline: biodistribution in mice after subcutaneous administration. J Drug Deliv Sci Technol. 2013;23(6):547–53. https://doi.org/10.1016/s1773-2247(13)50083-9 .
doi: 10.1016/s1773-2247(13)50083-9
Lv S, Jing R, Liu X, Shi H, Shi Y, Wang X, et al. One-step microfluidic fabrication of multi-responsive liposomes for targeted delivery of doxorubicin synergism with photothermal effect. Int J Nanomedicine. 2021;16:7759–72. https://doi.org/10.2147/ijn.S329621 .
doi: 10.2147/ijn.S329621 pubmed: 34848958 pmcid: 8627283
Cao X, Liu Q, Shi W, Liu K, Deng T, Weng X, et al. Microfluidic fabricated bisdemethoxycurcumin thermosensitive liposome with enhanced antitumor effect. Int J Pharm. 2023;641:123039. https://doi.org/10.1016/j.ijpharm.2023.123039 .
doi: 10.1016/j.ijpharm.2023.123039 pubmed: 37225026
Schuster B, Junkin M, Kashaf SS, Romero-Calvo I, Kirby K, Matthews J, et al. Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids. Nat Commun. 2020;11(1):5271. https://doi.org/10.1038/s41467-020-19058-4 .
doi: 10.1038/s41467-020-19058-4 pubmed: 33077832 pmcid: 7573629
Nguyen HQ, Seo TS. A 3D printed size-tunable flow-focusing droplet microdevice to produce cell-laden hydrogel microspheres. Anal Chim Acta. 2022;1192:339344. https://doi.org/10.1016/j.aca.2021.339344 .
doi: 10.1016/j.aca.2021.339344 pubmed: 35057943
Liu H, Singh RP, Zhang Z, Han X, Liu Y, Hu L. Microfluidic assembly: an innovative tool for the encapsulation, protection, and controlled release of nutraceuticals. J Agric Food Chem. 2021;69(10):2936–49. https://doi.org/10.1021/acs.jafc.0c05395 .
doi: 10.1021/acs.jafc.0c05395 pubmed: 33683870
Rajput MS, Agrawal P. Microspheres in cancer therapy. Indian J Cancer. 2010;47(4):458–68. https://doi.org/10.4103/0019-509x.73547 .
doi: 10.4103/0019-509x.73547 pubmed: 21131762
Hu C, He Y. Formononetin inhibits non-small cell lung cancer proliferation via regulation of mir-27a-3p through p53 pathway. Oncologie. 2021;23(2):241–50.
doi: 10.32604/Oncologie.2021.015828
Yu X, Gao F, Li W, Zhou L, Liu W, Li M. Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer. J Exp Clin Cancer Res. 2020;39(1):62. https://doi.org/10.1186/s13046-020-01566-2 .
doi: 10.1186/s13046-020-01566-2 pubmed: 32276600 pmcid: 7146989

Auteurs

Xia Cao (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Qingwen Li (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.
ORCID: 0009-0006-6240-0757

Xiaoli Li (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Qi Liu (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Kai Liu (K)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Tianwen Deng (T)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Xuedi Weng (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.

Qintong Yu (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Wenwen Deng (W)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Jiangnan Yu (J)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China.

Qilong Wang (Q)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China. 294353201@qq.com.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China. 294353201@qq.com.

Gao Xiao (G)

College of Environment and Safety Engineering, Fuzhou University, Fuzhou, 350108, Fujian, People's Republic of China. xgscu007@gmail.com.

Ximing Xu (X)

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, People's Republic of China. xmxu@ujs.edu.cn.
Medicinal function development of new food resources, Jiangsu Provincial Research Center, Jiangsu, People's Republic of China. xmxu@ujs.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Acide polyglycolique › Copolymère d'acide poly(lactique-co-glycolique) › Enhancing Anticancer Efficacy of Formononetin...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Enhancing Anticancer Efficacy of Formononetin...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Acide polyglycolique › Enhancing Anticancer Efficacy of Formononetin...
questionsmedicales.fr › Équipement et fournitures › Microsphères › Enhancing Anticancer Efficacy of Formononetin...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Microtechnologie › Microfluidique › Enhancing Anticancer Efficacy of Formononetin...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Enhancing Anticancer Efficacy of Formononetin...