A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids.
astragalus polysaccharides
flavonoids
natural carrier
permeability
self-assembly
solubility
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2023
2023
Historique:
received:
11
08
2023
accepted:
18
10
2023
medline:
1
12
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Enhancing the dissolution, permeation and absorption of active components with low solubility and poor permeability is crucial for maximizing therapeutic efficacy and optimizing functionality. The objective of this study is to investigate the potential of natural polysaccharides as carriers to improve the biopharmaceutical properties of active components. In this study, we employed four representative flavonoids in Astragali Radix, namely Calycosin The results showed that APS can self-assemble into aggregates with a porous structure and large surface area in aqueous solutions. These aggregates can be loaded with flavonoids through weak intermolecular interactions, such as hydrogen bonding, thereby improving their gastrointestinal stability, solubility, permeability and absorption in vivo. We discovered the self-assembly properties of APS and its potential as carriers. Compared with introducing external excipients, the utilization of natural polysaccharides in plants as carriers may have a unique advantage in enhancing dissolution, permeation and absorption.
Identifiants
pubmed: 38026532
doi: 10.2147/IJN.S434196
pii: 434196
pmc: PMC10656867
doi:
Substances chimiques
Flavonoids
0
Biological Products
0
Polysaccharides
0
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6705-6724Informations de copyright
© 2023 Yang et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Planta Med. 2017 Oct;83(14-15):1184-1193
pubmed: 28472840
J Chem Theory Comput. 2011 Dec 13;7(12):4026-37
pubmed: 26598349
Mol Pharm. 2006 Nov-Dec;3(6):631-43
pubmed: 17140251
Sci Adv. 2022 Jul;8(26):eabn3917
pubmed: 35767627
Food Chem. 2020 Nov 1;329:127158
pubmed: 32512394
Front Pharmacol. 2021 Jan 14;11:580978
pubmed: 33628171
Nat Commun. 2016 Feb 03;7:10604
pubmed: 26837579
Int J Biol Macromol. 2018 Sep;116:1011-1025
pubmed: 29800657
J Ethnopharmacol. 2008 May 8;117(2):378-84
pubmed: 18400430
Carbohydr Polym. 2020 Nov 1;247:116673
pubmed: 32829801
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Aug 15;1060:221-230
pubmed: 28628837
Food Funct. 2018 Feb 21;9(2):677-687
pubmed: 29292445
Int J Nanomedicine. 2020 Jun 12;15:4151-4169
pubmed: 32606670
Acta Pharm Sin B. 2015 Sep;5(5):442-53
pubmed: 26579474
Molecules. 2022 Feb 23;27(5):
pubmed: 35268609
Med Res Rev. 2021 Jul;41(4):1999-2038
pubmed: 33464616
Food Chem. 2023 Feb 15;402:134165
pubmed: 36126573
Adv Colloid Interface Sci. 2023 Feb;312:102846
pubmed: 36736167
Int J Biol Macromol. 2023 Apr 15;234:123767
pubmed: 36812962
Int J Biol Macromol. 2021 Jul 1;182:815-824
pubmed: 33857512
J Ethnopharmacol. 2022 Jan 10;282:114650
pubmed: 34536515
Nat Nanotechnol. 2020 Jul;15(7):605-614
pubmed: 32483319
J Comput Chem. 2012 Feb 15;33(5):580-92
pubmed: 22162017
Int J Nanomedicine. 2020 Sep 25;15:7097-7115
pubmed: 33061370
Mol Pharm. 2017 May 1;14(5):1610-1622
pubmed: 28394618
ACS Omega. 2022 Nov 20;7(48):43510-43521
pubmed: 36506183
Chin Med. 2023 Jun 6;18(1):66
pubmed: 37280646
Int J Mol Sci. 2022 Jul 27;23(15):
pubmed: 35955406
Int J Pharm. 2020 Feb 15;575:118980
pubmed: 31899320
ACS Appl Mater Interfaces. 2019 Mar 27;11(12):11936-11946
pubmed: 30843685
Int J Biol Macromol. 2020 Aug 15;157:452-460
pubmed: 32339577
Biomed Pharmacother. 2022 Feb;146:112531
pubmed: 34906771
Int J Biol Macromol. 2021 Dec 1;192:1240-1255
pubmed: 34678381
J Chem Theory Comput. 2018 Nov 13;14(11):5834-5845
pubmed: 30289710
Int J Nanomedicine. 2017 Apr 12;12:2957-2978
pubmed: 28442906
Chem Soc Rev. 2012 Apr 7;41(7):2623-40
pubmed: 22085917
Biomolecules. 2020 Jun 27;10(7):
pubmed: 32605030
Expert Opin Drug Metab Toxicol. 2019 Feb;15(2):167-177
pubmed: 30582378
Pharmaceuticals (Basel). 2022 Jul 12;15(7):
pubmed: 35890153
Int J Nanomedicine. 2019 Nov 21;14:9077-9088
pubmed: 31819420
Int J Biol Macromol. 2020 Jan 15;143:873-880
pubmed: 31712148
ACS Nano. 2019 Jun 25;13(6):6770-6781
pubmed: 31135129
Phys Chem Chem Phys. 2021 Sep 22;23(36):20323-20328
pubmed: 34486612
Int J Mol Sci. 2020 May 31;21(11):
pubmed: 32486445
Molecules. 2020 Aug 27;25(17):
pubmed: 32867101
Int J Biol Macromol. 2020 Apr 15;149:732-740
pubmed: 31987946
Adv Drug Deliv Rev. 2019 Jun;146:248-266
pubmed: 29966684
Ann N Y Acad Sci. 2017 Jun;1398(1):120-129
pubmed: 28436044
Antioxidants (Basel). 2020 Apr 13;9(4):
pubmed: 32295070
Small. 2016 Jan 6;12(1):96-119
pubmed: 26584451
Expert Opin Drug Deliv. 2020 Oct;17(10):1345-1359
pubmed: 32602795
Int J Mol Sci. 2023 Mar 07;24(6):
pubmed: 36982200
Phytomedicine. 2022 Nov;106:154432
pubmed: 36113188
Adv Colloid Interface Sci. 2020 Oct;284:102251
pubmed: 32949812