New insights into the stemness of adoptively transferred T cells by γc family cytokines.

Adoptive cell therapy (ACT) Stem cell-like memory T cells (TSCM) Stemness γc family cytokines

Journal

Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464

Informations de publication

Date de publication:
04 Dec 2023
Historique:
received: 30 08 2023
accepted: 11 10 2023
medline: 6 12 2023
pubmed: 5 12 2023
entrez: 4 12 2023
Statut: epublish

Résumé

T cell-based adoptive cell therapy (ACT) has exhibited excellent antitumoral efficacy exemplified by the clinical breakthrough of chimeric antigen receptor therapy (CAR-T) in hematologic malignancies. It relies on the pool of functional T cells to retain the developmental potential to serially kill targeted cells. However, failure in the continuous supply and persistence of functional T cells has been recognized as a critical barrier to sustainable responses. Conferring stemness on infused T cells, yielding stem cell-like memory T cells (T

Identifiants

pubmed: 38049832
doi: 10.1186/s12964-023-01354-3
pii: 10.1186/s12964-023-01354-3
pmc: PMC10694921
doi:

Substances chimiques

Cytokines 0

Types de publication

Video-Audio Media Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

347

Subventions

Organisme : the National Key Technology Research and Development Program of China
ID : 2022YFC2704200
Organisme : the National Key Technology Research and Development Program of China
ID : 2022YFC2704200
Organisme : the National Key Technology Research and Development Program of China
ID : 2022YFC2704200
Organisme : the National Key Technology Research and Development Program of China
ID : 2022YFC2704200
Organisme : the National Key Technology Research and Development Program of China
ID : 2022YFC2704200
Organisme : the National Key Technology Research and Development Program of China
ID : 2022YFC2704200
Organisme : National Natural Science Foundation of China
ID : 82272707, 81874109
Organisme : National Natural Science Foundation of China
ID : 82272707, 81874109
Organisme : National Natural Science Foundation of China
ID : 82272707, 81874109
Organisme : National Natural Science Foundation of China
ID : 82272707, 81874109
Organisme : National Natural Science Foundation of China
ID : 82272707, 81874109
Organisme : National Natural Science Foundation of China
ID : 82272707, 81874109

Informations de copyright

© 2023. The Author(s).

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Auteurs

Mengshi Luo (M)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Wenjian Gong (W)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Yuewen Zhang (Y)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Huayi Li (H)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Ding Ma (D)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Kongming Wu (K)

Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Qinglei Gao (Q)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. qingleigao@hotmail.com.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. qingleigao@hotmail.com.

Yong Fang (Y)

Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. tongjify@163.com.
National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. tongjify@163.com.

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