The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants.

Humans Autoimmunity / genetics Cell Differentiation Homozygote Intraepithelial Lymphocytes / immunology Receptors, Antigen, T-Cell, alpha-beta / genetics Membrane Glycoproteins / genetics Loss of Function Mutation Lymphocyte Count Alleles Infections / immunology Lymphoproliferative Disorders / immunology Pedigree Male Female Middle Aged Aged Aged, 80 and over

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
Mar 2024
Historique:
medline: 4 3 2024
pubmed: 29 2 2024
entrez: 29 2 2024
Statut: ppublish

Résumé

We describe humans with rare biallelic loss-of-function

Identifiants

DOI: 10.1126/science.adh4059 PMID: 38422122
pubmed: 38422122
doi: 10.1126/science.adh4059
doi:

Substances chimiques

Receptors, Antigen, T-Cell, alpha-beta 0
pre-T cell receptor alpha 0
Membrane Glycoproteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadh4059

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK127044
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States

Auteurs

Marie Materna (M)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0003-2145-5285

Ottavia M Delmonte (OM)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-4772-0799

Marita Bosticardo (M)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-1771-4523

Mana Momenilandi (M)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0002-5340-2762

Peyton E Conrey (PE)

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0001-7766-9878

Bénédicte Charmeteau-De Muylder (B)

University of Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.

Clotilde Bravetti (C)

Department of Biological Hematology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP) and Sorbonne Université, Paris, France.
Sorbonne University, Paris Cancer Institute CURAMUS, INSERM U1138, Paris, France.

Rebecca Bellworthy (R)

Deptartment of Human Genetics, Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
ORCID: 0009-0002-5878-1527

Axel Cederholm (A)

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
ORCID: 0009-0006-5973-9637

Frederik Staels (F)

Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

Christian A Ganoza (CA)

Centogene GmbH, Rostock, Germany.
ORCID: 0000-0002-5891-5372

Samuel Darko (S)

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-9711-8122

Samir Sayed (S)

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0003-4981-5721

Corentin Le Floc'h (C)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0009-0007-0590-0437

Masato Ogishi (M)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0003-2421-7389

Darawan Rinchai (D)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-8851-7730

Andrea Guenoun (A)

Department of Human Immunology, Sidra Medicine, Doha, Qatar.
ORCID: 0000-0002-4303-8653

Alexandre Bolze (A)

Helix, San Mateo, CA, USA.
ORCID: 0000-0001-7399-2766

Taushif Khan (T)

Department of Human Immunology, Sidra Medicine, Doha, Qatar.
The Jackson Laboratory, Farmington, CT, USA.
ORCID: 0000-0002-7917-8965

Adrian Gervais (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0002-1083-5787

Renate Krüger (R)

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.

Mirjam Völler (M)

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
ORCID: 0000-0003-1696-8561

Boaz Palterer (B)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-2499-8250

Mahnaz Sadeghi-Shabestari (M)

Immunology Research Center, TB and Lung Disease Research Center, Mardaniazar Children Hospital, Tabriz University of Medical Science, Tabriz, Iran.
ORCID: 0000-0001-5356-3163

Anne Langlois de Septenville (A)

Department of Biological Hematology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP) and Sorbonne Université, Paris, France.

Chaim A Schramm (CA)

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Sanjana Shah (S)

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

John J Tello-Cajiao (JJ)

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0002-7927-9467

Francesca Pala (F)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-4537-9061

Kayla Amini (K)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0009-0006-7911-1097

Jose S Campos (JS)

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0003-3344-7733

Noemia Santana Lima (NS)

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-4399-487X

Daniel Eriksson (D)

Department of Immunology, Genetics and Pathology, Uppsala University and University Hospital, Section of Clinical Genetics, Uppsala, Sweden.
ORCID: 0000-0001-5473-3312

Romain Lévy (R)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.
ORCID: 0000-0002-6393-0198

Yoann Seeleuthner (Y)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.

Soma Jyonouchi (S)

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Manar Ata (M)

Department of Human Immunology, Sidra Medicine, Doha, Qatar.
ORCID: 0000-0001-7111-5719

Fatima Al Ali (F)

Department of Human Immunology, Sidra Medicine, Doha, Qatar.
ORCID: 0000-0001-6451-7357

Caroline Deswarte (C)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0002-8775-3368

Anaïs Pereira (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0001-5821-5133

Jérôme Mégret (J)

Cytometry Core Facility, SFR Necker, INSERM US24-CNRS UAR3633, Paris, France.

Tom Le Voyer (T)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0002-0630-8626

Paul Bastard (P)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, Paris, France.
ORCID: 0000-0002-5926-8437

Laureline Berteloot (L)

Department of Pediatric Radiology, University Hospital Necker-Enfants Malades, AP-HP, Paris, France.
ORCID: 0000-0001-9681-3142

Michaël Dussiot (M)

Imagine Institute, University of Paris-Cité, Paris, France.
Laboratory of Molecular Mechanisms of Hematological Disorders and Therapeutic Implications, INSERM UMR 1163, Paris, France.

Natasha Vladikine (N)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.

Paula P Cardenas (PP)

Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
ORCID: 0000-0001-9054-8130

Emmanuelle Jouanguy (E)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0002-7358-9157

Mashael Alqahtani (M)

Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Amal Hasan (A)

Department of Translational Research, Research Division, Dasman Diabetes Institute, Dasman, Kuwait City, Kuwait.
ORCID: 0000-0002-1793-7794

Thangavel Alphonse Thanaraj (TA)

Department of Genetics and Bioinformatics, Research Division, Dasman Diabetes Institute, Dasman, Kuwait City, Kuwait.
ORCID: 0000-0002-4574-5343

Jérémie Rosain (J)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
ORCID: 0000-0002-2822-161X

Fahd Al Qureshah (F)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0002-5022-9917

Vito Sabato (V)

Department of Immunology, Allergology and Rheumatology, University of Antwerp, Antwerp University Hospital, Antwerp, Belgium.

Marie Alexandra Alyanakian (MA)

Immunology Laboratory, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Marianne Leruez-Ville (M)

Necker Hospital for Sick Children, AP-HP, Paris, France.
ORCID: 0000-0001-7513-7894

Flore Rozenberg (F)

University of Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
Virology, Cochin Hospital, AP-HP, APHP-CUP, Paris, France.

Elie Haddad (E)

Department of Pediatrics, Department of Microbiology, Immunology and Infectious Diseases, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada.
ORCID: 0000-0003-2446-6879

Jose R Regueiro (JR)

Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine and 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
ORCID: 0000-0001-8442-7762

Maria L Toribio (ML)

Immune System Development and Function Unit, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
ORCID: 0000-0002-8637-0373

Judith R Kelsen (JR)

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
ORCID: 0000-0003-0038-318X

Mansoor Salehi (M)

Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
ORCID: 0000-0002-6565-0907

Shahram Nasiri (S)

Department of Pediatric Neurology, Children's Medical Center of Abuzar, Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mehdi Torabizadeh (M)

Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Hassan Rokni-Zadeh (H)

Department of Medical Biotechnology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran.
ORCID: 0000-0001-5503-0344

Majid Changi-Ashtiani (M)

School of Mathematics, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
ORCID: 0000-0001-6428-9323

Nasimeh Vatandoost (N)

Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
ORCID: 0000-0003-0189-7529

Hossein Moravej (H)

Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Seyed Mohammad Akrami (SM)

Medical Genetics Poursina St., Genetic Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.
Dr. Shahrooei Laboratory, Tehran, Iran.
ORCID: 0000-0003-0169-0202

Mohsen Mazloomrezaei (M)

Dr. Shahrooei Laboratory, Tehran, Iran.
ORCID: 0000-0002-9296-9876

Aurélie Cobat (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-7209-6257

Isabelle Meyts (I)

Laboratory for Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Department of Pediatrics, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
ORCID: 0000-0003-1214-0302

Etsushi Toyofuku (E)

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.

Madoka Nishimura (M)

Department of Pediatrics, NHO Kumamoto Medical Center, Kumamoto, Japan.
ORCID: 0009-0007-6030-8567

Kunihiko Moriya (K)

Department of Pediatrics, National Defense Medical College, Saitama, Japan.
ORCID: 0000-0002-0418-5132

Tomoyuki Mizukami (T)

Department of Pediatrics, NHO Kumamoto Medical Center, Kumamoto, Japan.
ORCID: 0000-0002-2508-2810

Kohsuke Imai (K)

Department of Pediatrics, National Defense Medical College, Saitama, Japan.
ORCID: 0000-0003-2132-8403

Laurent Abel (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-7016-6493

Bernard Malissen (B)

Immunology Center of Marseille-Luminy, Aix Marseille University, Inserm, CNRS, Marseille, France.
Immunophenomics Center (CIPHE), Aix Marseille Université, Inserm, CNRS, Marseille, France.
ORCID: 0000-0003-1340-9342

Fahd Al-Mulla (F)

Department of Genetics and Bioinformatics, Research Division, Dasman Diabetes Institute, Dasman, Kuwait City, Kuwait.
ORCID: 0000-0001-5409-3829

Fowzan Sami Alkuraya (FS)

Department of Translational Genomics, Center for Genomic Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Department of Anatomy and Cell Biology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
ORCID: 0000-0003-4158-341X

Nima Parvaneh (N)

Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
ORCID: 0000-0002-3397-9716

Horst von Bernuth (H)

Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, Berlin, Germany.
Labor Berlin GmbH, Department of Immunology, Berlin, Germany.
ORCID: 0000-0002-5812-7675

Christian Beetz (C)

Centogene GmbH, Rostock, Germany.

Frédéric Davi (F)

Department of Biological Hematology, Hôpital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP) and Sorbonne Université, Paris, France.
Sorbonne University, Paris Cancer Institute CURAMUS, INSERM U1138, Paris, France.

Daniel C Douek (DC)

Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Rémi Cheynier (R)

University of Paris, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France.
ORCID: 0000-0003-1146-660X

David Langlais (D)

Deptartment of Human Genetics, Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, Canada.
ORCID: 0000-0003-4429-0110

Nils Landegren (N)

Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institute, Stockholm, Sweden.

Nico Marr (N)

Department of Human Immunology, Sidra Medicine, Doha, Qatar.
College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar.
ORCID: 0000-0002-1927-7072

Tomohiro Morio (T)

Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
ORCID: 0000-0002-9259-1025

Mohammad Shahrooei (M)

Dr. Shahrooei Laboratory, Tehran, Iran.
Clinical and Diagnostic Immunology, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.

Rik Schrijvers (R)

Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-4261-6220

Sarah E Henrickson (SE)

Division of Allergy Immunology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-5569-4132

Hervé Luche (H)

Immunophenomics Center (CIPHE), Aix Marseille Université, Inserm, CNRS, Marseille, France.
ORCID: 0000-0003-4309-8338

Luigi D Notarangelo (LD)

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-8335-0262

Jean-Laurent Casanova (JL)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France.
Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0002-7782-4169

Vivien Béziat (V)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University of Paris-Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0002-4020-824X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The immunopathological landscape of human...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › The immunopathological landscape of human...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The immunopathological landscape of human...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Homozygote › The immunopathological landscape of human...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes intra-épithéliaux › The immunopathological landscape of human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Récepteur lymphocytaire T antigène, alpha-bêta › The immunopathological landscape of human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › The immunopathological landscape of human...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › The immunopathological landscape of human...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Numération des lymphocytes › The immunopathological landscape of human...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › The immunopathological landscape of human...
questionsmedicales.fr › Infection › The immunopathological landscape of human...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › The immunopathological landscape of human...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Pedigree › The immunopathological landscape of human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The immunopathological landscape of human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › The immunopathological landscape of human...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › The immunopathological landscape of human...