Role of two modules controlling the interaction between SKAP1 and SRC kinases comparison with SKAP2 architecture and consequences for evolution.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2024
2024
Historique:
received:
07
12
2023
accepted:
28
02
2024
medline:
18
3
2024
pubmed:
14
3
2024
entrez:
14
3
2024
Statut:
epublish
Résumé
SRC kinase associated phosphoprotein 1 (SKAP1), an adaptor for protein assembly, plays an important role in the immune system such as stabilizing immune synapses. Understanding how these functions are controlled at the level of the protein-protein interactions is necessary to describe these processes and to develop therapeutics. Here, we dissected the SKAP1 modular organization to recognize SRC kinases and compared it to that of its paralog SRC kinase associated phosphoprotein 2 (SKAP2). Different conserved motifs common to either both proteins or specific to SKAP2 were found using this comparison. Two modules harboring different binding properties between SKAP1 and SKAP2 were identified: one composed of two conserved motifs located in the second interdomain interacting at least with the SH2 domain of SRC kinases and a second one composed of the DIM domain modulated by the SH3 domain and the activation of SRC kinases. This work suggests a convergent evolution of the binding properties of some SRC kinases interacting specifically with either SKAP1 or SKAP2.
Identifiants
pubmed: 38483858
doi: 10.1371/journal.pone.0296230
pii: PONE-D-23-40560
pmc: PMC10939263
doi:
Substances chimiques
src kinase associated phosphoprotein 2
0
src-Family Kinases
EC 2.7.10.2
Phosphoproteins
0
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0296230Informations de copyright
Copyright: © 2024 Levillayer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Semin Cell Dev Biol. 2020 Mar;99:31-39
pubmed: 30031213
iScience. 2021 Jul 16;24(8):102871
pubmed: 34386732
PLoS One. 2012;7(5):e36310
pubmed: 22615764
Oncotarget. 2018 Feb 6;9(17):13102-13115
pubmed: 29568343
Curr Opin Struct Biol. 2008 Jun;18(3):349-57
pubmed: 18448325
Mol Cell. 2008 Nov 21;32(4):564-75
pubmed: 19026786
Nucleic Acids Res. 2016 Jul 8;44(W1):W344-50
pubmed: 27166375
Acc Chem Res. 2017 May 16;50(5):1193-1201
pubmed: 28426203
J Biol Chem. 2002 Oct 25;277(43):40420-7
pubmed: 12171928
ACS Chem Biol. 2016 Sep 16;11(9):2551-7
pubmed: 27428792
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8779-84
pubmed: 9671755
Mol Cell Proteomics. 2010 Nov;9(11):2391-404
pubmed: 20627867
Cell. 2014 Nov 20;159(5):1212-1226
pubmed: 25416956
Biochim Biophys Acta. 2008 Jan;1784(1):56-65
pubmed: 17905674
Elife. 2020 Apr 30;9:
pubmed: 32352382
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
J Cell Biol. 2013 Dec 23;203(6):1021-41
pubmed: 24368808
Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20
pubmed: 25514926
Biochem Biophys Res Commun. 2002 Nov 8;298(4):501-4
pubmed: 12408980
FEBS Lett. 2012 Aug 14;586(17):2597-605
pubmed: 22569091
Nat Commun. 2021 Mar 12;12(1):1597
pubmed: 33712617
Trends Biochem Sci. 2015 Nov;40(11):628-647
pubmed: 26481499
Biochem Biophys Res Commun. 1998 Nov 27;252(3):738-42
pubmed: 9837776
Mol Cell. 2012 Jun 29;46(6):884-92
pubmed: 22749401
Nucleic Acids Res. 1988 Mar 11;16(5):1829-36
pubmed: 2832831
J Neurochem. 2016 Feb;136(3):637-50
pubmed: 26561212
New Biol. 1989 Oct;1(1):66-74
pubmed: 2488273
BMC Res Notes. 2018 Dec 6;11(1):869
pubmed: 30522503
Nucleic Acids Res. 2012 Jan;40(Database issue):D242-51
pubmed: 22110040
Nat Methods. 2015 Jan;12(1):7-8
pubmed: 25549265
Mol Cell Proteomics. 2023 Jan;22(1):100451
pubmed: 36423812
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17237-42
pubmed: 17085597
J Mol Biol. 2012 Jan 13;415(2):443-53
pubmed: 22198293
Curr Opin Struct Biol. 2017 Jun;44:201-210
pubmed: 28575754
Cell. 2015 Oct 22;163(3):594-606
pubmed: 26478181
Trends Cell Biol. 2008 Oct;18(10):486-93
pubmed: 18760924
Dev Genes Evol. 2015 Nov;225(6):353-7
pubmed: 26481129
Proc Natl Acad Sci U S A. 1988 Jun;85(12):4232-6
pubmed: 2454466
J Mol Biol. 2001 Mar 16;307(1):447-63
pubmed: 11243830
Arch Biochem Biophys. 2014 Jul 15;554:65-75
pubmed: 24853495
Nat Methods. 2011 Nov 29;8(12):990-2
pubmed: 22127214
Front Immunol. 2023 May 31;14:1192838
pubmed: 37325633
J Biol Chem. 2001 Jun 22;276(25):22375-81
pubmed: 11301322
Glia. 2021 Nov;69(11):2699-2716
pubmed: 34324225
Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2517-28
pubmed: 22889904
Mol Cell Biol. 2017 Mar 17;37(7):
pubmed: 28052935
FEBS Lett. 1998 Sep 11;435(1):55-60
pubmed: 9755858
Sci Rep. 2019 Jul 18;9(1):10462
pubmed: 31320682
Blood. 2012 Jan 19;119(3):777-85
pubmed: 22117043
J Cell Sci. 2012 Nov 15;125(Pt 22):5535-45
pubmed: 22976304
FEBS Lett. 2003 Apr 10;540(1-3):111-6
pubmed: 12681493
J Biol Chem. 2013 Jan 11;288(2):1171-83
pubmed: 23161539
Sci Signal. 2010 May 04;3(120):ra34
pubmed: 20442417
Biophys J. 2014 Oct 7;107(7):1686-96
pubmed: 25296322
Curr Biol. 1999 Aug 26;9(16):927-30
pubmed: 10469599
Immunity. 2010 Apr 23;32(4):541-56
pubmed: 20346707
Mol Cell Biol. 2010 Sep;30(17):4094-107
pubmed: 20584982
Mol Cell Biol. 2006 Oct;26(19):7130-44
pubmed: 16980616
PLoS Pathog. 2020 May 11;16(5):e1008576
pubmed: 32392230
Genome Biol Evol. 2019 Aug 1;11(8):2292-2305
pubmed: 31364708
Pharmacol Res. 2015 Apr;94:9-25
pubmed: 25662515
Cell. 2016 Feb 11;164(4):805-17
pubmed: 26871637
EMBO J. 2003 Jul 15;22(14):3486-92
pubmed: 12853464
J Chem Phys. 2023 Feb 28;158(8):081001
pubmed: 36859094
J Mol Biol. 2001 Oct 19;313(2):399-416
pubmed: 11800565
Genome Biol Evol. 2016 Sep 19;8(9):2806-25
pubmed: 27519537
Nat Rev Drug Discov. 2016 Aug;15(8):533-50
pubmed: 27050677
Oncogene. 2000 Nov 20;19(49):5548-57
pubmed: 11114734
J Mol Biol. 2003 Jan 31;325(5):991-1018
pubmed: 12527304
J Cell Sci. 2009 Apr 1;122(Pt 7):965-75
pubmed: 19258394
Crit Rev Biochem Mol Biol. 2018 Oct;53(5):535-563
pubmed: 30183386
Nat Commun. 2017 Jul 12;8:16001
pubmed: 28699640
J Immunol. 2002 Mar 15;168(6):2595-8
pubmed: 11884421