Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.

Humans Colorectal Neoplasms / genetics Genetic Predisposition to Disease Genome-Wide Association Study Asian People / genetics White People / genetics Polymorphism, Single Nucleotide Quantitative Trait Loci Exome Sequencing Case-Control Studies Transcriptome Chromosome Mapping Male Female East Asian People

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
26 Apr 2024
Historique:
received: 16 10 2023
accepted: 26 03 2024
medline: 27 4 2024
pubmed: 27 4 2024
entrez: 26 4 2024
Statut: epublish

Résumé

Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.

Identifiants

DOI: 10.1038/s41467-024-47399-x PMID: 38670944
pubmed: 38670944
doi: 10.1038/s41467-024-47399-x
pii: 10.1038/s41467-024-47399-x
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

3557

Subventions

Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01CA188214
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R37CA227130

Informations de copyright

© 2024. The Author(s).

Références

Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021).
pubmed: 33538338 doi: 10.3322/caac.21660
Jiao, S. et al. Estimating the heritability of colorectal cancer. Hum. Mol. Genet. 23, 3898–3905 (2014).
pubmed: 24562164 pmcid: 4065150 doi: 10.1093/hmg/ddu087
Lu, Y. et al. Large-scale genome-wide association study of east asians identifies loci associated with risk for colorectal cancer. Gastroenterology 156, 1455–1466 (2019).
pubmed: 30529582 doi: 10.1053/j.gastro.2018.11.066
Huyghe, J. R. et al. Discovery of common and rare genetic risk variants for colorectal cancer. Nat. Genet. 51, 76–87 (2019).
pubmed: 30510241 doi: 10.1038/s41588-018-0286-6
Law, P. J. et al. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nat. Commun. 10, 2154 (2019).
pubmed: 31089142 pmcid: 6517433 doi: 10.1038/s41467-019-09775-w
Lu, Y. et al. Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians. Cancer Epidemiol. Biomark. Prev. 29, 477–486 (2020).
doi: 10.1158/1055-9965.EPI-19-0755
Fernandez-Rozadilla, C. et al. Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries. Nat. Genet. 55, 89–99 (2023).
pubmed: 36539618 doi: 10.1038/s41588-022-01222-9
Zeng, C. et al. Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Res. 18 (2016).
Guo, X. et al. A comprehensive cis-eQTL analysis revealed target genes in breast cancer susceptibility loci identified in genome-wide association studies. Am. J. Hum. Genet. 102, 890–903 (2018).
pubmed: 29727689 pmcid: 5986971 doi: 10.1016/j.ajhg.2018.03.016
Chen, Z. et al. Identifying putative susceptibility genes and evaluating their associations with somatic mutations in human cancers. Am. J. Hum. Genet. 105, 477–492 (2019).
pubmed: 31402092 pmcid: 6731359 doi: 10.1016/j.ajhg.2019.07.006
Yuan, Y. et al. Multi-omics analysis to identify susceptibility genes for colorectal cancer. Hum. Mol. Genet. 30, 321–330 (2021).
pubmed: 33481017 pmcid: 8485221 doi: 10.1093/hmg/ddab021
Fachal, L. et al. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat. Genet. 52, 56–73 (2020).
pubmed: 31911677 pmcid: 6974400 doi: 10.1038/s41588-019-0537-1
Thiagalingam, A. et al. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Mol. Cell. Biol. 16, 5335–5345 (1996).
pubmed: 8816445 pmcid: 231532 doi: 10.1128/MCB.16.10.5335
Oliva, M. et al. DNA methylation QTL mapping across diverse human tissues provides molecular links between genetic variation and complex traits. Nat. Genet. 55, 112–122 (2023).
pubmed: 36510025 doi: 10.1038/s41588-022-01248-z
Wu, Y. et al. Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes. Cell Genom. 3, 100344 (2023).
pubmed: 37601976 pmcid: 10435383 doi: 10.1016/j.xgen.2023.100344
Guo, X. et al. Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects. Gastroenterology 160, 1164–1178.e6 (2021).
pubmed: 33058866 doi: 10.1053/j.gastro.2020.08.062
Chen, Z. et al. Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation. J. Natl Cancer Inst. https://doi.org/10.1093/jnci/djad178 (2023).
doi: 10.1093/jnci/djad178 pubmed: 37806780 pmcid: 10483263
Chen, B. et al. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 184, 6262–6280.e26 (2021).
pubmed: 34910928 pmcid: 8941949 doi: 10.1016/j.cell.2021.11.031
Chen, E. Y. et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform. 14, 128 (2013).
doi: 10.1186/1471-2105-14-128
Kuleshov, M. V. et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44, W90–W97 (2016).
pubmed: 27141961 pmcid: 4987924 doi: 10.1093/nar/gkw377
Xie, Z. et al. Gene set knowledge discovery with Enrichr. Curr. Protoc. 1, e90 (2021).
pubmed: 33780170 pmcid: 8152575 doi: 10.1002/cpz1.90
Jung, B., Staudacher, J. J. & Beauchamp, D. Transforming growth factor β superfamily signaling in development of colorectal cancer. Gastroenterology 152, 36–52 (2017).
pubmed: 27773809 doi: 10.1053/j.gastro.2016.10.015
Feng, Q., Li, S., Ma, H.-M., Yang, W.-T. & Zheng, P.-S. LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6high cervical cancer stem cells. Oncogene 40, 6103–6114 (2021).
pubmed: 34489551 pmcid: 8530990 doi: 10.1038/s41388-021-02002-1
Ruan, X. et al. Silencing LGR6 attenuates stemness and chemoresistance via inhibiting Wnt/β-catenin signaling in ovarian cancer. Mol. Ther. Oncolytics 14, 94–106 (2019).
pubmed: 31193124 pmcid: 6517611 doi: 10.1016/j.omto.2019.04.002
Dong, L., Lyu, X., Faleti, O. D. & He, M.-L. The special stemness functions of Tbx3 in stem cells and cancer development. Semin. Cancer Biol. 57, 105–110 (2019).
pubmed: 30268432 doi: 10.1016/j.semcancer.2018.09.010
Russell, R. et al. A dynamic role of TBX3 in the pluripotency circuitry. Stem Cell Rep. 5, 1155–1170 (2015).
doi: 10.1016/j.stemcr.2015.11.003
Elbadawy, M., Usui, T., Yamawaki, H. & Sasaki, K. Emerging roles of C-Myc in cancer stem cell-related signaling and resistance to cancer chemotherapy: A potential therapeutic target against colorectal cancer. Int. J. Mol. Sci. 20, 2340 (2019).
pubmed: 31083525 pmcid: 6539579 doi: 10.3390/ijms20092340
Satoh, K. et al. Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC. Proc. Natl Acad. Sci. USA 114, E7697–E7706 (2017).
pubmed: 28847964 pmcid: 5604037 doi: 10.1073/pnas.1710366114
Ong, E. S. et al. Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis. Mol. Cell. Proteom. https://doi.org/10.1074/mcp.M900551-MCP200 (2010).
doi: 10.1074/mcp.M900551-MCP200
Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190–2191 (2010).
pubmed: 20616382 pmcid: 2922887 doi: 10.1093/bioinformatics/btq340
Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369–375 (2012).
pubmed: 22426310 pmcid: 3593158 doi: 10.1038/ng.2213
Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011).
pubmed: 21167468 pmcid: 3014363 doi: 10.1016/j.ajhg.2010.11.011
Zhang, B. et al. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat. Genet. 46, 533–542 (2014).
pubmed: 24836286 pmcid: 4068797 doi: 10.1038/ng.2985
Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15–21 (2013).
pubmed: 23104886 doi: 10.1093/bioinformatics/bts635
Graubert, A., Aguet, F., Ravi, A., Ardlie, K. G. & Getz, G. RNA-SeQC 2: Efficient RNA-seq quality control and quantification for large cohorts. Bioinformatics 37, 3048–3050 (2021).
pubmed: 33677499 pmcid: 8479667 doi: 10.1093/bioinformatics/btab135
Frankish, A. et al. GENCODE: reference annotation for the human and mouse genomes in 2023. Nucleic Acids Res. 51, D942–D949 (2023).
pubmed: 36420896 doi: 10.1093/nar/gkac1071
Díez-Villanueva, A. et al. Identifying causal models between genetically regulated methylation patterns and gene expression in healthy colon tissue. Clin. Epigenetics 13, 162 (2021).
pubmed: 34419169 pmcid: 8380335 doi: 10.1186/s13148-021-01148-9
Díez-Villanueva, A. et al. DNA methylation events in transcription factors and gene expression changes in colon cancer. Epigenomics 12, 1593–1610 (2020).
pubmed: 32957849 doi: 10.2217/epi-2020-0029
Zhu, Z. et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat. Genet. 48, 481–487 (2016).
pubmed: 27019110 doi: 10.1038/ng.3538
Zheng, R. et al. Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis. Nucleic Acids Res. 47, D729–D735 (2019).
pubmed: 30462313 doi: 10.1093/nar/gky1094
Mei, S. et al. Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse. Nucleic Acids Res. 45, D658–D662 (2017).
pubmed: 27789702 doi: 10.1093/nar/gkw983
Johnstone, S. E. et al. Large-scale topological changes restrain malignant progression in colorectal cancer. Cell 182, 1474–1489.e23 (2020).
pubmed: 32841603 pmcid: 7575124 doi: 10.1016/j.cell.2020.07.030
Orouji, E. et al. Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer. Gut 71, 938–949 (2022).
pubmed: 34059508 doi: 10.1136/gutjnl-2020-322835
Li, Q.-L. et al. Genome-wide profiling in colorectal cancer identifies PHF19 and TBC1D16 as oncogenic super enhancers. Nat. Commun. 12, 6407 (2021).
pubmed: 34737287 pmcid: 8568941 doi: 10.1038/s41467-021-26600-5
Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008).
pubmed: 18798982 pmcid: 2592715 doi: 10.1186/gb-2008-9-9-r137
Orlando, G. et al. Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer. Nat. Genet. 50, 1375–1380 (2018).
pubmed: 30224643 pmcid: 6380472 doi: 10.1038/s41588-018-0211-z
He, B., Chen, C., Teng, L. & Tan, K. Global view of enhancer-promoter interactome in human cells. Proc. Natl Acad. Sci. USA 111, E2191–E2199 (2014).
pubmed: 24821768 pmcid: 4040567 doi: 10.1073/pnas.1320308111
Lizio, M. et al. Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biol. 16, 22 (2015).
pubmed: 25723102 pmcid: 4310165 doi: 10.1186/s13059-014-0560-6
Andersson, R. et al. An atlas of active enhancers across human cell types and tissues. Nature 507, 455–461 (2014).
pubmed: 24670763 pmcid: 5215096 doi: 10.1038/nature12787
Gao, T. & Qian, J. EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue/cell types across nine species. Nucleic Acids Res. 48, D58–D64 (2020).
pubmed: 31740966
Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934–947 (2013).
pubmed: 24119843 doi: 10.1016/j.cell.2013.09.053
Jiang, Y. et al. SEdb: a comprehensive human super-enhancer database. Nucleic Acids Res. 47, D235–D243 (2019).
pubmed: 30371817 doi: 10.1093/nar/gky1025
Lajoie, B. R., Dekker, J. & Kaplan, N. The Hitchhiker’s guide to Hi-C analysis: practical guidelines. Methods 72, 65–75 (2015).
pubmed: 25448293 doi: 10.1016/j.ymeth.2014.10.031
McLaren, W. et al. The ensembl variant effect predictor. Genome Biol. 17 (2016).
Bailey, M. H. et al. Comprehensive characterization of cancer driver genes and mutations. Cell 173, 371–385.e18 (2018).
pubmed: 29625053 pmcid: 6029450 doi: 10.1016/j.cell.2018.02.060
Yang, H. & Wang, K. Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR. Nat. Protoc. 10, 1556–1566 (2015).
pubmed: 26379229 pmcid: 4718734 doi: 10.1038/nprot.2015.105
Kim, S., Jhong, J.-H., Lee, J. & Koo, J.-Y. Meta-analytic support vector machine for integrating multiple omics data. BioData Min. 10, 2 (2017).
pubmed: 28149325 pmcid: 5270233 doi: 10.1186/s13040-017-0126-8
zhishanchen. zhishanchen/CRC_Finemapping: crc_finemapping. (Zenodo, 2024). https://doi.org/10.5281/ZENODO.10645372

Auteurs

Zhishan Chen (Z)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Xingyi Guo (X)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
ORCID: 0000-0001-5269-1294

Ran Tao (R)

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, 37232, TN, USA.

Jeroen R Huyghe (JR)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
ORCID: 0000-0001-6027-9806

Philip J Law (PJ)

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
ORCID: 0000-0001-9663-4611

Ceres Fernandez-Rozadilla (C)

Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.
Genomic Medicine Group, Instituto de Investigacion Sanitaria de Santiago, Santiago de Compostela, Spain.
ORCID: 0000-0001-7330-4804

Jie Ping (J)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0001-9907-5819

Guochong Jia (G)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-8455-1832

Jirong Long (J)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Chao Li (C)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Quanhu Shen (Q)

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0001-8951-9295

Yuhan Xie (Y)

Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
ORCID: 0000-0002-1738-0885

Maria N Timofeeva (MN)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Danish Institute for Advanced Study, Department of Public Health, University of Southern Denmark, Odense, Denmark.
ORCID: 0000-0002-2503-4253

Minta Thomas (M)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
ORCID: 0000-0001-9337-7015

Stephanie L Schmit (SL)

Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Population and Cancer Prevention Program, Case Comprehensive Cancer Center, Cleveland, OH, USA.
ORCID: 0000-0001-5931-1194

Virginia Díez-Obrero (V)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain.

Matthew Devall (M)

Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
ORCID: 0000-0001-5943-4397

Ferran Moratalla-Navarro (F)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain.
ORCID: 0000-0001-7858-5713

Juan Fernandez-Tajes (J)

Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.

Claire Palles (C)

Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
ORCID: 0000-0002-9670-2263

Kitty Sherwood (K)

Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.
ORCID: 0009-0007-4055-607X

Sarah E W Briggs (SEW)

Department of Public Health, Richard Doll Building, University of Oxford, Oxford, UK.
ORCID: 0000-0002-1844-0755

Victoria Svinti (V)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Kevin Donnelly (K)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-7633-9113

Susan M Farrington (SM)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-5955-7389

James Blackmur (J)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Peter G Vaughan-Shaw (PG)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Yingchang Lu (Y)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Peter Broderick (P)

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
ORCID: 0000-0002-8348-5829

James Studd (J)

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
ORCID: 0000-0002-7157-754X

Tabitha A Harrison (TA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

David V Conti (DV)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Fredrick R Schumacher (FR)

Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
ORCID: 0000-0002-3073-7463

Marilena Melas (M)

The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Gad Rennert (G)

Clalit National Cancer Control Center, Haifa, Israel.
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
ORCID: 0000-0002-8512-068X

Mireia Obón-Santacana (M)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.
Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain.

Vicente Martín-Sánchez (V)

Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.
Biomedicine Institute, University of León, León, Spain.
ORCID: 0000-0003-0552-2804

Jae Hwan Oh (JH)

Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea.

Jeongseon Kim (J)

Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea.
ORCID: 0000-0002-0889-2686

Sun Ha Jee (SH)

Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea.

Keum Ji Jung (KJ)

Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea.
ORCID: 0000-0003-4993-0666

Sun-Seog Kweon (SS)

Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.

Min-Ho Shin (MH)

Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
ORCID: 0000-0002-2217-5624

Aesun Shin (A)

Cancer Research Institute, Seoul National University, Seoul, South Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
ORCID: 0000-0002-6426-1969

Yoon-Ok Ahn (YO)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Dong-Hyun Kim (DH)

Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, South Korea.

Isao Oze (I)

Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
ORCID: 0000-0002-0762-1147

Wanqing Wen (W)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-3004-5168

Keitaro Matsuo (K)

Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
ORCID: 0000-0003-1761-6314

Koichi Matsuda (K)

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.
ORCID: 0000-0001-7292-2686

Chizu Tanikawa (C)

Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Zefang Ren (Z)

School of Public Health, Sun Yat-sen University, Guangzhou, China.
ORCID: 0000-0002-7785-4704

Yu-Tang Gao (YT)

State Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Wei-Hua Jia (WH)

State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
ORCID: 0000-0002-0528-8715

John L Hopper (JL)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.

Mark A Jenkins (MA)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
ORCID: 0000-0002-8964-6160

Aung Ko Win (AK)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
ORCID: 0000-0002-2794-5261

Rish K Pai (RK)

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Jane C Figueiredo (JC)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Robert W Haile (RW)

Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, Los Angeles, CA, USA.
ORCID: 0000-0001-6902-1836

Steven Gallinger (S)

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
ORCID: 0000-0002-6998-9414

Michael O Woods (MO)

Division of Biomedical Sciences, Memorial University of Newfoundland, St. John, ON, Canada.

Polly A Newcomb (PA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
School of Public Health, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-8786-0043

David Duggan (D)

City of Hope National Medical Center, Translational Genomics Research Institute, Phoenix, AZ, USA.

Jeremy P Cheadle (JP)

Institute of Medical Genetics, Cardiff University, Cardiff, UK.
ORCID: 0000-0001-9453-8458

Richard Kaplan (R)

MRC Clinical Trials Unit, Medical Research Council, Cardiff, UK.
ORCID: 0000-0002-0189-8348

Rachel Kerr (R)

Department of Oncology, University of Oxford, Oxford, UK.

David Kerr (D)

Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
ORCID: 0000-0001-7811-6722

Iva Kirac (I)

Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Jan Böhm (J)

Department of Pathology, Central Finland Health Care District, Jyväskylä, Finland.

Jukka-Pekka Mecklin (JP)

Central Finland Health Care District, Jyväskylä, Finland.

Pekka Jousilahti (P)

Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0001-7190-0979

Paul Knekt (P)

Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

Lauri A Aaltonen (LA)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0001-6839-4286

Harri Rissanen (H)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

Eero Pukkala (E)

Faculty of Social Sciences, Tampere University, Tampere, Finland.
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.

Johan G Eriksson (JG)

Folkhälsan Research Centre, University of Helsinki, Helsinki, Finland.
Human Potential Translational Research Programme, National University of Singapore, Singapore, Singapore.
Unit of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Tatiana Cajuso (T)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-6354-5572

Ulrika Hänninen (U)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0003-1558-0450

Johanna Kondelin (J)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

Kimmo Palin (K)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4621-6128

Tomas Tanskanen (T)

Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.
Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

Laura Renkonen-Sinisalo (L)

Department of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.

Satu Männistö (S)

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
ORCID: 0000-0002-8668-3046

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-3834-1535

Edward Ruiz-Narvaez (E)

Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-0339-5824

Julie R Palmer (JR)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Slone Epidemiology Center at Boston University, Boston, MA, USA.

Daniel D Buchanan (DD)

Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, Parkville, VIC, Australia.
Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC, Australia.
University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia.
ORCID: 0000-0003-2225-6675

Elizabeth A Platz (EA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
ORCID: 0000-0003-3676-8954

Kala Visvanathan (K)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
ORCID: 0000-0002-0582-8005

Cornelia M Ulrich (CM)

Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.

Erin Siegel (E)

Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
ORCID: 0000-0003-1779-2510

Stefanie Brezina (S)

Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.
ORCID: 0000-0001-5238-6900

Andrea Gsur (A)

Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.
ORCID: 0000-0002-9795-1528

Peter T Campbell (PT)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany.
ORCID: 0000-0001-8919-1971

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
ORCID: 0000-0002-8307-3197

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany.
German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany.
ORCID: 0000-0002-6129-1572

Martha L Slattery (ML)

Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

John D Potter (JD)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Research Centre for Hauora and Health, Massey University, Wellington, New Zealand.
ORCID: 0000-0001-5439-1500

Kostas K Tsilidis (KK)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.

Matthias B Schulze (MB)

Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.
ORCID: 0000-0002-0830-5277

Marc J Gunter (MJ)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.

Neil Murphy (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
ORCID: 0000-0003-3347-8249

Antoni Castells (A)

Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0001-8431-2033

Sergi Castellví-Bel (S)

Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0003-1217-5097

Leticia Moreira (L)

Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0002-4518-8591

Volker Arndt (V)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
ORCID: 0000-0001-9320-8684

Anna Shcherbina (A)

Department of Genetics, Stanford University, Stanford, CA, USA.

D Timothy Bishop (DT)

Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
ORCID: 0000-0002-8752-8785

Graham G Giles (GG)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Melissa C Southey (MC)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.
ORCID: 0000-0002-6313-9005

Gregory E Idos (GE)

Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA.

Kevin J McDonnell (KJ)

Clalit National Cancer Control Center, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA.

Zomoroda Abu-Ful (Z)

Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.

Joel K Greenson (JK)

Clalit National Cancer Control Center, Haifa, Israel.
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

Katerina Shulman (K)

Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.

Flavio Lejbkowicz (F)

Clalit National Cancer Control Center, Haifa, Israel.
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel.

Kenneth Offit (K)

Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

Yu-Ru Su (YR)

Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Robert Steinfelder (R)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
ORCID: 0000-0003-4204-8013

Temitope O Keku (TO)

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.

Bethany van Guelpen (B)

Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-9692-101X

Thomas J Hudson (TJ)

Ontario Institute for Cancer Research, Toronto, ON, Canada.

Heather Hampel (H)

Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Rachel Pearlman (R)

Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Richard B Hayes (RB)

Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA.
ORCID: 0000-0002-0918-661X

Marie Elena Martinez (ME)

Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
Population Sciences, Disparities and Community Engagement, University of California San Diego Moores Cancer Center, La Jolla, CA, USA.

Sushma S Thomas (SS)

Fred Hutchinson Cancer Center, Seattle, WA, USA.

Paul D P Pharoah (PDP)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Susanna C Larsson (SC)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-0118-0341

Yun Yen (Y)

Taipei Medical University, Taipei, Taiwan.
ORCID: 0000-0003-0815-412X

Heinz-Josef Lenz (HJ)

Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0003-2178-9568

Emily White (E)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.

Li Li (L)

Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.

Kimberly F Doheny (KF)

Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0001-8806-5738

Elizabeth Pugh (E)

Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Tameka Shelford (T)

Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Andrew T Chan (AT)

Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7284-6767

Marcia Cruz-Correa (M)

Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico.

Annika Lindblom (A)

Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

David J Hunter (DJ)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Amit D Joshi (AD)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.

Clemens Schafmayer (C)

Department of General Surgery, University Hospital Rostock, Rostock, Germany.

Peter C Scacheri (PC)

Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.

Anshul Kundaje (A)

Department of Genetics, Stanford University, Stanford, CA, USA.
Department of Computer Science, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-3084-2287

Robert E Schoen (RE)

Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
ORCID: 0000-0001-7153-2766

Jochen Hampe (J)

Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany.
ORCID: 0000-0002-2421-6127

Zsofia K Stadler (ZK)

Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-6985-2864

Pavel Vodicka (P)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Ludmila Vodickova (L)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Veronika Vymetalkova (V)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Christopher K Edlund (CK)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

W James Gauderman (WJ)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

David Shibata (D)

Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.

Amanda Toland (A)

Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
ORCID: 0000-0002-0271-1792

Sanford Markowitz (S)

Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA.
ORCID: 0000-0001-5369-5254

Andre Kim (A)

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0002-2324-3393

Franzel van Duijnhoven (F)

Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.

Edith J M Feskens (EJM)

Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands.
ORCID: 0000-0001-5819-2488

Lori C Sakoda (LC)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
ORCID: 0000-0002-0900-5735

Manuela Gago-Dominguez (M)

Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-7387-6845

Barbara Pardini (B)

Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy.
Italian Institute for Genomic Medicine, Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy.
ORCID: 0000-0001-9571-4257

Liesel M FitzGerald (LM)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Soo Chin Lee (SC)

National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

Shuji Ogino (S)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA, USA.
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-3909-2323

Stephanie A Bien (SA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Charles Kooperberg (C)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
ORCID: 0000-0002-7986-8560

Christopher I Li (CI)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Yi Lin (Y)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Ross Prentice (R)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

Conghui Qu (C)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.

Stéphane Bézieau (S)

Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France.
ORCID: 0000-0003-0095-1319

Taiki Yamaji (T)

Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.

Norie Sawada (N)

Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
ORCID: 0000-0002-9936-1476

Motoki Iwasaki (M)

Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.
Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan.

Loic Le Marchand (L)

Cancer Center, University of Hawaii, Honolulu, HI, USA.

Anna H Wu (AH)

Preventative Medicine, University of Southern California, Los Angeles, CA, USA.

Chenxu Qu (C)

USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Caroline E McNeil (CE)

USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Gerhard Coetzee (G)

Van Andel Research Institute, Grand Rapids, MI, USA.
ORCID: 0000-0001-8820-8364

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-9405-9550

Ian J Deary (IJ)

Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-1733-263X

Sarah E Harris (SE)

Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-4941-5106

Evropi Theodoratou (E)

Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-5887-9132

Stuart Reid (S)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Marion Walker (M)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Li Yin Ooi (LY)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore.
ORCID: 0000-0002-5588-2130

Ken S Lau (KS)

Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
ORCID: 0000-0001-8438-0319

Hongyu Zhao (H)

Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
ORCID: 0000-0003-1195-9607

Li Hsu (L)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-8168-4712

Qiuyin Cai (Q)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-9384-5648

Malcolm G Dunlop (MG)

Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-3033-5851

Stephen B Gruber (SB)

Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA.
ORCID: 0000-0001-8656-7822

Richard S Houlston (RS)

Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
ORCID: 0000-0002-5268-0242

Victor Moreno (V)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain.
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain.
ORCID: 0000-0002-2818-5487

Graham Casey (G)

Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

Ulrike Peters (U)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Department of Epidemiology, University of Washington, Seattle, WA, USA.
ORCID: 0000-0001-5666-9318

Ian Tomlinson (I)

Edinburgh Cancer Research Centre, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK.
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA. wei.zheng@vanderbilt.edu.
ORCID: 0000-0003-1226-070X

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Personnes › Asiatiques › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Personnes › Blancs › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Séquençage de l'exome › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Cartographie chromosomique › Fine-mapping analysis including over 254,000...
questionsmedicales.fr › Personnes › Asiatiques › Peuples d'Asie de l'Est › Fine-mapping analysis including over 254,000...