Predictability of B cell clonal persistence and immunosurveillance in breast cancer.
Humans
Female
Breast Neoplasms
/ immunology
B-Lymphocytes
/ immunology
Immunologic Surveillance
Receptors, Antigen, T-Cell
/ genetics
Receptors, Antigen, B-Cell
/ metabolism
T-Lymphocytes
/ immunology
Monitoring, Immunologic
Exome Sequencing
Antigens, Neoplasm
/ immunology
Neoplasm Metastasis
Clone Cells
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
received:
20
02
2024
accepted:
15
03
2024
medline:
3
5
2024
pubmed:
3
5
2024
entrez:
2
5
2024
Statut:
ppublish
Résumé
B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clones. B cell clonal immunosurveillance and temporal persistence are predictable from the clonal structure, with higher-centrality B cell antigen receptors more likely to be detected across multiple metastases or across time. This predictability was generalizable across other immune-mediated disorders. This work lays a foundation for prioritizing antibody sequences for therapeutic targeting in cancer.
Identifiants
pubmed: 38698238
doi: 10.1038/s41590-024-01821-0
pii: 10.1038/s41590-024-01821-0
doi:
Substances chimiques
Receptors, Antigen, T-Cell
0
Receptors, Antigen, B-Cell
0
Antigens, Neoplasm
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
916-924Subventions
Organisme : Academy of Medical Sciences
ID : SGL028\1074
Pays : United Kingdom
Informations de copyright
© 2024. The Author(s).
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