Lethal Capecitabine Toxicity in Patients With Complete Dihydropyrimidine Dehydrogenase Deficiency Due to Ultra-Rare

Humans Dihydropyrimidine Dehydrogenase Deficiency / genetics Capecitabine / adverse effects Dihydrouracil Dehydrogenase (NADP) / genetics Antimetabolites, Antineoplastic / adverse effects Male Female Fatal Outcome Middle Aged

Journal

JCO precision oncology
ISSN: 2473-4284
Titre abrégé: JCO Precis Oncol
Pays: United States
ID NLM: 101705370

Informations de publication

Date de publication:
May 2024
Historique:
medline: 6 5 2024
pubmed: 6 5 2024
entrez: 6 5 2024
Statut: ppublish

Résumé

A DPD deficiency should be considered in case of severe toxicity even in the absence of common risk variants in DPYD.

Identifiants

DOI: 10.1200/PO.23.00599 PMID: 38709992
pubmed: 38709992
doi: 10.1200/PO.23.00599
doi:

Substances chimiques

Capecitabine 6804DJ8Z9U
Dihydrouracil Dehydrogenase (NADP) EC 1.3.1.2
Antimetabolites, Antineoplastic 0

Types de publication

Journal Article Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2300599

Auteurs

André B P van Kuilenburg (ABP)

Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
ORCID: 0000-0002-7989-4910

Marjolein C H Pleunis-van Empel (MCH)

Medisch Spectrum Twente, Department of Oncology, Enschede, the Netherlands.

Rick B Brouwer (RB)

Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Medlon BV, Enschede, the Netherlands.

Angelique E J Sijben (AEJ)

Department of Neurology, Medisch Spectrum Twente, Enschede, the Netherlands.

Daan G Knapen (DG)

Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-2523-137X

Thijs H Oude Munnink (TH)

Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-8392-5858

Jelmer J van Zanden (JJ)

Martini Hospital Groningen, Certe Department of Clinical Chemistry, the Netherlands.

Jenny Janssens-Puister (J)

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Doreen Dobritzsch (D)

Department of Chemistry, Uppsala University, Biomedical Center, Uppsala, Sweden.

Rutger Meinsma (R)

Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.

Judith Meijer-Jansen (J)

Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.

Silvy J M van Dooren (SJM)

Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.

Raymon Vijzelaar (R)

MRC-Holland bv, Amsterdam, the Netherlands.

Ana Pop (A)

Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.

Gajja S Salomons (GS)

Amsterdam University Medical Center, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Amsterdam, the Netherlands.
ORCID: 0000-0003-2509-3648

Jan Gerard Maring (JG)

Departments of Clinical Pharmacy and Medical Oncology, Isala, Zwolle, the Netherlands.
ORCID: 0009-0009-8533-9233

Klary E Niezen-Koning (KE)

Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-9384-4354

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lethal Capecitabine Toxicity in Patients With...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme de la purine et de la pyrimidine › Déficit en dihydropyrimidine déshydrogénase › Lethal Capecitabine Toxicity in Patients With...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Désoxycytidine › Capécitabine › Lethal Capecitabine Toxicity in Patients With...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Dihydrouracil dehydrogenase (NADP) › Lethal Capecitabine Toxicity in Patients With...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Antimétabolites › Antimétabolites antinéoplasiques › Lethal Capecitabine Toxicity in Patients With...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Issue fatale › Lethal Capecitabine Toxicity in Patients With...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Lethal Capecitabine Toxicity in Patients With...