Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase.

Multigene Family Streptomyces / genetics Polyketide Synthases / genetics Peptide Synthases / metabolism Bacterial Proteins / genetics
chain release mechanism chalkophore copper hybrid NRPS/PKS peptide reductase domain (R0)

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
25 Apr 2024
Historique:
received: 14 03 2024
revised: 17 04 2024
accepted: 23 04 2024
medline: 11 5 2024
pubmed: 11 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

Chalkophomycin is a novel chalkophore with antibiotic activities isolated from

Identifiants

DOI: 10.3390/molecules29091982 PMID: 38731473
pubmed: 38731473
pii: molecules29091982
doi: 10.3390/molecules29091982
pii:
doi:

Substances chimiques

Polyketide Synthases 79956-01-7
non-ribosomal peptide synthase EC 6.3.2.-
Peptide Synthases EC 6.3.2.-
Bacterial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : 82373772
Organisme : National Natural Science Foundation of China
ID : 82204256
Organisme : Hunan Provincial Natural Science Foundation of China
ID : 2022JJ40408
Organisme : Chinese Ministry of Education 111 Project
ID : BP0820034

Auteurs

Long Yang (L)

Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Hefei Comprehensive National Science Center, Institute of Health and Medicine, Hefei 230093, China.

Liwei Yi (L)

Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Department of Pharmacy, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.
ORCID: 0000-0001-6314-3277

Bang Gong (B)

Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
College of Pharmacy, Hunan Vocational College of Science and Technology, Changsha 410004, China.

Lili Chen (L)

Hefei Comprehensive National Science Center, Institute of Health and Medicine, Hefei 230093, China.

Miao Li (M)

Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.

Xiangcheng Zhu (X)

Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha 410011, China.
National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha 410011, China.

Yanwen Duan (Y)

Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.
Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha 410011, China.
National Engineering Research Center of Combinatorial Biosynthesis for Drug Discovery, Changsha 410011, China.

Yong Huang (Y)

Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Hefei Comprehensive National Science Center, Institute of Health and Medicine, Hefei 230093, China.
Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, China.

Articles similaires

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

Initial pH determines the morphological characteristics and secondary metabolite production in Aspergillus terreus and Streptomyces rimosus cocultures.

Tomasz Boruta, Martyna Foryś, Weronika Pawlikowska et al.
1.00
Aspergillus Hydrogen-Ion Concentration Coculture Techniques Secondary Metabolism Streptomyces rimosus

Systematical characterization of Rab7 gene family in Gossypium and potential functions of GhRab7B3-A gene in drought tolerance.

Mengyuan Yan, Zhiwei Dong, Tian Pan et al.
1.00
Drought Resistance Gene Expression Profiling Gene Expression Regulation, Plant Gossypium Multigene Family

Two codependent routes lead to high-level MRSA.

Abimbola Feyisara Adedeji-Olulana, Katarzyna Wacnik, Lucia Lafage et al.
1.00
Methicillin-Resistant Staphylococcus aureus Penicillin-Binding Proteins Peptidoglycan Bacterial Proteins Anti-Bacterial Agents

Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Chalkophomycin Biosynthesis Revealing Unique...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets sporulés à Gram positif › Streptomycetaceae › Streptomyces › Chalkophomycin Biosynthesis Revealing Unique...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Polyketide synthases › Chalkophomycin Biosynthesis Revealing Unique...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-nitrogen ligases › Amino-acid ligases › Chalkophomycin Biosynthesis Revealing Unique...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Chalkophomycin Biosynthesis Revealing Unique...