Revealing Genetic Dynamics: scRNA-seq Unravels Modifications in Human PDL Cells across In Vivo and In Vitro Environments.

Humans Periodontal Ligament / cytology Single-Cell Analysis / methods Cells, Cultured RNA-Seq / methods Sequence Analysis, RNA / methods Male Female Gene Expression Profiling / methods Adult Transcriptome Single-Cell Gene Expression Analysis
culture conditions genetic markers periodontal ligament cells single-cell RNA-seq

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Apr 2024
Historique:
received: 23 03 2024
revised: 15 04 2024
accepted: 22 04 2024
medline: 11 5 2024
pubmed: 11 5 2024
entrez: 11 5 2024
Statut: epublish

Résumé

The periodontal ligament (PDL) is a highly specialized fibrous tissue comprising heterogeneous cell populations of an intricate nature. These complexities, along with challenges due to cell culture, impede a comprehensive understanding of periodontal pathophysiology. This study aims to address this gap, employing single-cell RNA sequencing (scRNA-seq) technology to analyze the genetic intricacies of PDL both in vivo and in vitro. Primary human PDL samples (

Identifiants

DOI: 10.3390/ijms25094731 PMID: 38731950
pubmed: 38731950
pii: ijms25094731
doi: 10.3390/ijms25094731
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Ali T Abdallah (AT)

Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), 50931 Cologne, Germany.
Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University of Cologne, 50923 Cologne, Germany.
Interdisciplinary Center for Clinical Research, University Hospital RWTH, 52074 Aachen, Germany.

Michael Peitz (M)

Institute of Reconstructive Neurobiology, Life and Brain Center, University Hospital Bonn, 53105 Bonn, Germany.

Anna Konermann (A)

Department of Orthodontics, University Hospital Bonn, 53111 Bonn, Germany.
ORCID: 0000-0003-0266-6095

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Système stomatognathique › Bouche › Denture › Parodonte › Desmodonte › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Cellules › Cellules cultivées › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › RNA-Seq › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Revealing Genetic Dynamics: scRNA-seq Unravels...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Analyse de l'expression du gène de la cellule unique › Revealing Genetic Dynamics: scRNA-seq Unravels...