Advances and prospects in microbial production of biotin.

Biotin / biosynthesis Metabolic Engineering / methods Synthetic Biology / methods
Biosynthetic pathway Biotin Chemical mutagenesis Metabolic engineering

Journal

Microbial cell factories
ISSN: 1475-2859
Titre abrégé: Microb Cell Fact
Pays: England
ID NLM: 101139812

Informations de publication

Date de publication:
12 May 2024
Historique:
received: 25 01 2024
accepted: 30 04 2024
medline: 13 5 2024
pubmed: 13 5 2024
entrez: 12 5 2024
Statut: epublish

Résumé

Biotin, serving as a coenzyme in carboxylation reactions, is a vital nutrient crucial for the natural growth, development, and overall well-being of both humans and animals. Consequently, biotin is widely utilized in various industries, including feed, food, and pharmaceuticals. Despite its potential advantages, the chemical synthesis of biotin for commercial production encounters environmental and safety challenges. The burgeoning field of synthetic biology now allows for the creation of microbial cell factories producing bio-based products, offering a cost-effective alternative to chemical synthesis for biotin production. This review outlines the pathway and regulatory mechanism involved in biotin biosynthesis. Then, the strategies to enhance biotin production through both traditional chemical mutagenesis and advanced metabolic engineering are discussed. Finally, the article explores the limitations and future prospects of microbial biotin production. This comprehensive review not only discusses strategies for biotin enhancement but also provides in-depth insights into systematic metabolic engineering approaches aimed at boosting biotin production.

Identifiants

DOI: 10.1186/s12934-024-02413-1 PMID: 38735926
pubmed: 38735926
doi: 10.1186/s12934-024-02413-1
pii: 10.1186/s12934-024-02413-1
doi:

Substances chimiques

Biotin 6SO6U10H04

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

135

Subventions

Organisme : National Natural Science Foundation of China
ID : 22208368
Organisme : National Natural Science Foundation of China
ID : 22178372
Organisme : Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project
ID : TSBICIP-CXRC-070
Organisme : Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project
ID : TSBICIP-KJGG-011
Organisme : National Key R&D Program of China
ID : 2021YFC2100700
Organisme : Youth Innovation Promotion Association, Chinese Academy of Sciences
ID : 2020182
Organisme : Liaoning Province Education Sciences Foundation
ID : LJKMZ20220886
Organisme : National Science Fund for Distinguished Young Scholars
ID : 22325807

Informations de copyright

© 2024. The Author(s).

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Auteurs

Donghan Ma (D)

School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, China.
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, China.
Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Guangqing Du (G)

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, China.
Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Huan Fang (H)

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, China.
Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Rong Li (R)

School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, China. lirong@dlpu.edu.cn.

Dawei Zhang (D)

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. zhang_dw@tib.cas.cn.
National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, China. zhang_dw@tib.cas.cn.
Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. zhang_dw@tib.cas.cn.
University of Chinese Academy of Sciences, Beijing, 100049, China. zhang_dw@tib.cas.cn.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Coenzymes › Biotine › Advances and prospects in microbial production...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Génie métabolique › Advances and prospects in microbial production...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Biologie synthétique › Advances and prospects in microbial production...