Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein.

Intramolecular Lyases / metabolism Acyltransferases / metabolism Plant Proteins / metabolism Flavonoids / metabolism Kinetics Flavanones / chemistry Chalcones / chemistry Substrate Specificity Crystallography, X-Ray Molecular Docking Simulation Models, Molecular Protein Binding Protein Conformation
Panicum virgatum Sorghum bicolor anthocyanidins anthocyanin flavones flavonols metabolon

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
22 May 2024
Historique:
received: 04 04 2024
revised: 16 05 2024
accepted: 18 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

Chalcone synthase (CHS) and chalcone isomerase (CHI) catalyze the first two committed steps of the flavonoid pathway that plays a pivotal role in the growth and reproduction of land plants, including UV protection, pigmentation, symbiotic nitrogen fixation, and pathogen resistance. Based on the obtained X-ray crystal structures of CHS, CHI, and chalcone isomerase-like protein (CHIL) from the same monocotyledon,

Identifiants

DOI: 10.3390/ijms25115651 PMID: 38891840
pubmed: 38891840
pii: ijms25115651
doi: 10.3390/ijms25115651
pii:
doi:

Substances chimiques

chalcone isomerase EC 5.5.1.6
flavanone synthetase EC 2.3.1.74
Intramolecular Lyases EC 5.5.-
Acyltransferases EC 2.3.-
Plant Proteins 0
Flavonoids 0
Flavanones 0
naringenin chalcone 73692-50-9
Chalcones 0
naringenin HN5425SBF2
isoliquiritigenin B9CTI9GB8F

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : USDA-NIFA
ID : 2023-67013-39629
Organisme : USDA-ARS
ID : 3042-21000-034-00D
Organisme : USDA-ARS
ID : 3042-21220-032-00D
Organisme : NSF
ID : MCB-2043248

Auteurs

Jacob A Lewis (JA)

Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
ORCID: 0000-0001-6430-7034

Eric P Jacobo (EP)

Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
ORCID: 0000-0002-7127-0468

Nathan Palmer (N)

Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, NE 68583, USA.

Wilfred Vermerris (W)

Department of Microbiology & Cell Science and UF Genetics Institute, University of Florida, Gainesville, FL 32610, USA.
ORCID: 0000-0002-4582-3436

Scott E Sattler (SE)

Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, NE 68583, USA.
ORCID: 0000-0002-6814-4073

James A Brozik (JA)

Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
ORCID: 0000-0003-2097-5051

Gautam Sarath (G)

Department of Agriculture-Agricultural Research Service, Wheat, Sorghum, and Forage Research Unit, Lincoln, NE 68583, USA.

ChulHee Kang (C)

Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
ORCID: 0000-0002-0693-7860

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › Lyases intramoléculaires › Structural and Interactional Analysis of the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Structural and Interactional Analysis of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Structural and Interactional Analysis of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Structural and Interactional Analysis of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Structural and Interactional Analysis of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavanones › Structural and Interactional Analysis of the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Chalcones › Structural and Interactional Analysis of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Structural and Interactional Analysis of the...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural and Interactional Analysis of the...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Structural and Interactional Analysis of the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural and Interactional Analysis of the...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural and Interactional Analysis of the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural and Interactional Analysis of the...