Endophytic Aspergillus fumigatiaffinis: Novel paclitaxel production and optimization insights.
Aspergillus fumigatiaffinis
Design of experiment
Endophytic
Optimization
Paclitaxel
Taxol®
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
03 Jul 2024
03 Jul 2024
Historique:
received:
07
04
2024
accepted:
07
06
2024
revised:
21
05
2024
medline:
3
7
2024
pubmed:
3
7
2024
entrez:
3
7
2024
Statut:
epublish
Résumé
This study investigated the potential of endophytic fungi to produce paclitaxel (Taxol®), a potent anticancer compound widely employed in chemotherapy. This research aimed to identify, confirm, and characterize endophytic fungi capable of paclitaxel (PTX) production and assess their paclitaxel yield. Additionally, it aimed to investigate factors influencing paclitaxel production. A total of 100 endophytic fungal isolates were collected and identified from the roots of Artemisia judaica. Aspergillus fumigatiaffinis exhibited the highest PTX production (26.373 μg L
Identifiants
pubmed: 38958755
doi: 10.1007/s00253-024-13230-2
pii: 10.1007/s00253-024-13230-2
doi:
Substances chimiques
Paclitaxel
P88XT4IS4D
Culture Media
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
405Informations de copyright
© 2024. The Author(s).
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